Results 281 to 290 of about 512,927 (317)
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Synthetic tumor microenvironments
Nature Methods, 2021An artificial system models the mechanical properties of the tumor microenvironment in vitro.
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Pancreatic Tumor Microenvironment
2020The pancreatic ductal adenocarcinoma (PDAC) microenvironment is a diverse and complex milieu of immune, stromal, and tumor cells and is characterized by a dense stroma, which mediates the interaction between the tumor and the immune system within the tumor microenvironment (TME).
Kai, Wang, Hong, He
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Adipose Tumor Microenvironment
2020The term "adipose tissue" represents a multicellular and multifunctional organ involved in lipid storage, in hormone and temperature regulation, and in the protection of bones and vital organs from impact-based damage. Emerging evidence now suggests a more malignant role of adipose tissue in promoting cancer onset and progression via the release of ...
Abbie, Zewdu +3 more
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Gastric Tumor Microenvironment
2020A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided new insights into the multiple molecular mechanisms, defined by genetic and epigenetic mechanisms, supporting a very active cross talk
Armando, Rojas +3 more
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The tumor microenvironment at a glance
Journal of Cell Science, 2012Cancers are not just masses of malignant cells but complex ‘rogue’ organs, to which many other cells are recruited and can be corrupted by the transformed cells. Interactions between malignant and non-transformed cells create the tumor microenvironment (TME).
Frances R, Balkwill +2 more
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Thrombospondin in Tumor Microenvironment
2020Thrombospondins (TSPs) are multifaceted proteins that contribute to physiologic as well as pathologic conditions. Due to their multiple receptor-binding domains, TSPs display both oncogenic and tumor-suppressive qualities and are thus essential components of the extracellular matrix.
Divya, Ramchandani, Vivek, Mittal
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Appendix Tumor Microenvironment
2020The pathological features of the appendix tumors fundamentally recall those of the more frequent colorectal neoplasms, although with a higher relative incidence of carcinoids, due to the abundant presence of enteroendocrine cells in the appendix wall. Moreover, different types of lymphomas, Hodgkin and non-Hodgkin, arising from the extra-nodal mucosal ...
Luca, Roncati +5 more
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Leptin in Tumor Microenvironment
2020Leptin is a hormone that plays a major role as mediator of long-term regulation of energy balance, suppressing food intake, and stimulating weight loss. More recently, important physiological roles other than controlling appetite and energy expenditure have been suggested for leptin, including neuroendocrine, reparative, reproductive, and immune ...
Angelucci, A, Clementi, L, Alesse, E
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Fibroblasts in the Tumor Microenvironment
2020The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors.
Truffi M., Sorrentino L., Corsi F.
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Esophageal Tumor Microenvironment
2020Treatment options for patients with esophageal cancer are limited and the overall survival is disappointing. While surgical resection remains the only curative treatment option, there is a need for innovative medical therapies to extend patient survival.
Henrik, Nienhüser +2 more
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