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Versican in the Tumor Microenvironment
2020Versican is an extracellular matrix proteoglycan with nonredundant roles in diverse biological and cellular processes, ranging from embryonic development to adult inflammation and cancer. Versican is essential for cardiovascular morphogenesis, neural crest migration, and skeletal development during embryogenesis.
Athanasios, Papadas +1 more
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Thrombospondins in the tumor microenvironment
Seminars in Cell & Developmental BiologyMany cancers begin with the formation of a small nest of transformed cells that can remain dormant for years. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, a key early step in tumor progression. Over time, increases in drivers of angiogenesis predominate, and vascular cells, immune cells, and fibroblasts are ...
James, Petrik +3 more
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Imaging the Tumor Microenvironment
2017The tumor microenvironment consists of tumor, stromal, and immune cells, as well as extracellular milieu. Changes in numbers of these cell types and their environments have an impact on cancer growth and metastasis. Non-invasive imaging of aspects of the tumor microenvironment can provide important information on the aggressiveness of the cancer ...
Marie-Caline Z, Abadjian +2 more
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Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment
Cell Metabolism, 2021Fatemeh Vahedi +2 more
exaly
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Cell, 2020Brian C Miller +2 more
exaly
B Cell Function in the Tumor Microenvironment
Annual Review of Immunology, 2022Benjamin Vincent +2 more
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