Results 161 to 170 of about 492,012 (208)

A Comparative Observational Study on the Effect of Leptin in Regulating Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-<i>α</i>) in Patients with Alcoholic Hepatitis in a Tertiary Healthcare Setting.

J Pharm Bioallied Sci
Shankari CS, Ramasamy J, Moorthi VV, Kaliyamoorthy S, Sambandam R, Karthik PM.   +5 more
europepmc   +1 more source

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Tumor Necrosis Factor-Alpha Antagonist-Induced Sarcoidosis

JCR: Journal of Clinical Rheumatology, 2010
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Tumor necrosis factor (TNF)-alpha is an important player in granuloma formation, and recent clinical trials have investigated the efficacy of TNF-alpha inhibitors in sarcoidosis. Paradoxically, there are several case reports in the medical literature describing the development of ...
Clementine, Rochelle Robicheaux, Lyman, Justin, Zakem, Jerald, Mallepalli, Jyothi, Lindsey, Stephen, Quinet, Robert   +5 more
openaire   +3 more sources

Tumor necrosis factor alpha in mycobacterial infection

Seminars in Immunology, 2014
Tumor necrosis factor alpha (TNF-α) is a critical immune mediator in protection against and pathology of tuberculosis (TB). TNF-α had been found to be associated with TB when it was originally identified as cachexin and until today TB research continues to unveil novel roles of this cytokine of highest relevance for the disease process and for novel ...
Dorhoi, A., Kaufmann, S.
openaire   +3 more sources

[Tumor necrosis factor alpha].

Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1992
TNF-alpha (Cachectin) is a cytokine (tissue hormone) synthesized and secreted as a trimeric polypeptide; major producers are the cells of the RES after stimulation, e.g. by endotoxin. Its synthesis is strictly regulated. TNF elicits a great number of cell-specific responses. IL-1 and probably additional mediators cooperate in these effects.
C S, Rock, S F, Lowry
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Serum Tumor Necrosis Factor-Alpha in Neonatal Sepsis

American Journal of Perinatology, 1997
Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates with septicemia and compared with the levels of gestational-postnatal, age-matched healthy controls.
Atici A., Satar M., Çetíner S., Yaman A.   +3 more
openaire   +3 more sources

Nano anti-tumor necrosis factor-alpha based potentiometric sensor for tumor necrosis factor-alpha detection

Sensors and Actuators B: Chemical, 2015
Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan, Özkütük, Ebru Birlik, Ünlüer, Özlem Biçen, Uğurag, Deniz, Ersöz, Arzu   +4 more
openaire   +2 more sources

Four epitopes on tumor necrosis factor-alpha defined by murine anti-tumor necrosis factor-alpha monoclonal antibodies

Immunology Letters, 1994
Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim, R, Béliard, J J, Huart, D, Bourel   +3 more
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Tumor necrosis factor alpha disrupts tight junction assembly

Journal of Surgical Research, 2004
We have previously shown an increase in intestinal permeability and a corresponding decrease in the expression of tight junction (TJ) proteins in the in testines of patients with Crohn's disease (CD). Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin,
Lisa S, Poritz, Kristian I, Garver, Anna F, Tilberg, Walter A, Koltun   +3 more
openaire   +2 more sources

Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists

American Journal of Therapeutics, 2013
The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Justin, Gan, Augustine M, Manadan, Winston, Sequiera, Joel A, Block   +3 more
openaire   +2 more sources

Role of tumor necrosis factor alpha in asthma

Immunology and Allergy Clinics of North America, 2004
Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such
Babu, K. Suresh, Davies, Donna E., Holgate, Stephen T.   +2 more
openaire   +3 more sources