Results 71 to 80 of about 648,894 (406)

The effects of exercise modalities on adiposity in obese rats [PDF]

, 2012
OBJECTIVE: The aim of the present study was to evaluate the effect of both swimming and resistance training on tumor necrosis factor-alpha and interleukin-10 expression, adipocyte area and lipid profiles in rats fed a high-fat diet.
Andre, Rafael Arquias, Araujo, Heloisa Sobreiro Selistre de, Duarte, Ana Claudia Garcia de Oliveira, Duarte, Fernanda Oliveira, Leite, Richard Diego, Lino, Anderson Diogo de Souza, Rosante, Marisa Cristina, Silvestre, João Guilherme de Oliveira, Speretta, Guilherme Fleury Fina   +8 more
core   +4 more sources

Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Infliximab in Pediatric Inflammatory Bowel Disease: A Systematic Review and Revised Dosing Considerations [PDF]

, 2020
OBJECTIVES: Infliximab (IFX), a monoclonal antibody directed against tumor necrosis factor alpha is a potent treatment option for inflammatory bowel disease (IBD).
Escher, J.C. (Johanna), Joosse, M.E. (Linda), Ridder, L. (Lissy) de, Taminiau, J.A., Wildt, S.N. (Saskia) de, Winter, D.A. (Dwight A.)   +5 more
core   +1 more source

Tumor necrosis factor alpha gene polymorphism in Serbian patients with sarcoidosis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2013
Introduction. Sarcoidosis is a multisystemic disease of unknown etiology. Genetic factors play a considerable role in the onset of the disease. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine which plays an important role in the ...
Rađenović-Petković Tatjana, Pejčić Tatjana, Videnović-Ivanov Jelica, Jevtović-Stoimenov Tatjana, Janković Irena, Nastasijević-Borovac Desa, Radojković Danijela   +6 more
doaj   +1 more source

Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease [PDF]

, 2012
Background Chronic obstructive pulmonary disease (COPD) is characterized by progressive worsening of airflow limitation associated with abnormally inflamed airways in older smokers.
Baribaud, Frédéric, Barnathan, Elliot S, Loza, Matthew J, Rennard, Stephen I, Watt, Rosemary   +4 more
core   +3 more sources

Targeted Cancer Therapy with Tumor Necrosis Factor-Alpha [PDF]

Biochemistry Insights, 2008
Tumor necrosis factor-alpha (TNF-α), a member of the TNF superfamily, was the first cytokine to be evaluated for cancer biotherapy. However, the clinical use of TNF-α is severely limited by its toxicity. Currently, TNF-α is administered only through locoregional drug delivery systems such as isolated limb perfusion and isolated hepatic perfusion.
Weibo Cai, Hao Hong, Zachary Kerner, Jiangtao Sun   +3 more
openaire   +3 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil.

American Journal of Clinical Nutrition, 1996
The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers.
G. Caughey, E. Mantzioris, R. Gibson, L. Cleland, M. James   +4 more
semanticscholar   +1 more source

Hubungan antara Tumor Necrosis Factor Alpha dengan Demam Berdarah Dengue

Sari Pediatri, 2016
Latar belakang. Sampai saat ini patogenesis demam berdarah dengue (DBD) belum dipahami secara sempurna. Pada kasus DBD didapatkan adanya peningkatan kadar TNF-α, sitokin yang poten dalam meningkatkan permeabilitas pembuluh darah.
Felix Candra Sutanto, Max F.J. Mantik, Vivekenanda Pateda   +2 more
doaj   +1 more source

The relationships between eicosanoid production and pro-inflammatory cytokines [PDF]

, 2001
Explores alternate strategies that may alter inflammatory cytokine production, particularly tumour necrosis factor α [tumor necrosis factor-alpha], and therefore provide a possible treatment for rheumatoid arthritis.Thesis (Ph.D.) -- University of ...
Penglis, Peter Savas
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