Results 311 to 320 of about 729,544 (396)

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Effect of Non-surgical Periodontal Therapy on Levels of Ghrelin and Tumor Necrosis Factor-Alpha (TNF-α) in the Gingival Crevicular Fluid of Healthy and Periodontitis Patients With and Without Type 2 Diabetes Mellitus: A Clinico-Biochemical Study. [PDF]

Cureus
Ram MBK, A N S, Pai BSJ, Jayaram P.
europepmc   +1 more source

The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration.

, 1993
Eija Korpelainen, Jennifer R. Gamble, William Smith, Gregory J. Goodall, Smith Jim Q., Joanna M. Woodcock, Mara Dottore, Mathew A. Vadas, Angel F. López   +8 more
openalex   +2 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha Inhibits the Replication of Patient-Derived Archetype BK Polyomavirus While Activating Rearranged Strains. [PDF]

J Med Virol
Lauterbach-Rivière L, Thuringer L, Feld P, Toews LK, Schüssler J, Klinz J, Gläser L, Lohse S, Sternjakob A, Gasparoni G, Kattler-Lackes K, Walter J, Lauterbach MA, Rahmann S, Möller L, Laue M, Janssen M, Stöckle M, Schmit D, Fliser D, Smola S.   +20 more
europepmc   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha Inhibitor Use and Malignancy Risk: A Systematic Review and Patient Level Meta-Analysis. [PDF]

Cancers (Basel)
Driscoll CB, Rich JM, Isaacson D, Nicolas J, Jiang Y, Mi X, Yang C, Kocsuta V, Goh R, Patel N, Li E, Siddiqui MR, Meyers T, Witte JS, Kachuri L, Zhang H, Beestrum M, Silberman P, Schaeffer EM, Kundu SD.   +19 more
europepmc   +1 more source

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

Advanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li, Jinlong Xu, Zujie Gao, Haosheng Chen   +3 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha: Ally and Enemy in Protean Cutaneous Sceneries. [PDF]

Int J Mol Sci
Pocino K, Carnazzo V, Stefanile A, Basile V, Guerriero C, Marino M, Rigante D, Basile U.   +7 more
europepmc   +1 more source