Results 271 to 280 of about 34,617,262 (326)

Regulation and dysregulation of tumor necrosis factor receptor-1.

Cytokine & Growth Factor Reviews, 2014
TNF is an essential regulator of the immune system. Dysregulation of TNF plays a role in the pathology of many auto-immune diseases. TNF-blocking agents have proven successful in the treatment of such diseases. Development of novel, safer or more effective drugs requires a deeper understanding of the regulation of the pro-inflammatory activities of TNF
L. Puimège   +2 more
semanticscholar   +3 more sources

Tumor necrosis factor receptor 1 inhibition is therapeutic for neuropathic pain in males but not in females

Pain, 2018
Tumor necrosis factor (TNF) is a proinflammatory cytokine, which is involved in physiological and pathological processes and has been found to be crucial for pain development.
Tania Del Rivero   +4 more
semanticscholar   +1 more source

Solution structure of the tumor necrosis factor receptor-1 death domain

Journal of Molecular Biology, 2001
Tumor necrosis factor receptor-1 death domain (TNFR-1 DD) is the intracellular functional domain responsible for the receptor signaling activities. The solution structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy. A total of 20 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of ...
S F, Sukits   +5 more
openaire   +2 more sources

Tumor necrosis factor receptor 1 expression and early spontaneous abortion

International Journal of Gynecology & Obstetrics, 2004
AbstractObjectivesTo compare tumor necrosis factor receptor 1 (TNFR1) protein expression in women with unexplained early spontaneous abortion (UESA) and normal pregnancy.MethodsIn a prospective study, 62 women with UESA and 60 with normal pregnancy were studied.
X W, Yu, C F, Yan, H, Jin, X, Li
openaire   +2 more sources

Characterization of a recombinant extracellular domain of the type 1 tumor necrosis factor receptor: evidence for tumor necrosis factor .alpha. induced receptor aggregation

Biochemistry, 1992
An expression plasmid encoding the extracellular portion of the human tumor necrosis factor (TNF) type 1 receptor (TNF-R1) was constructed and used to generate a stable cell line secreting soluble TNF-R1 (sTNF-R1). The sTNF-R1 was purified, and its biochemical properties and its interactions with human TNF-alpha were examined.
D, Pennica   +7 more
openaire   +2 more sources

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