Results 281 to 290 of about 34,617,262 (326)

Graft Tumor Necrosis Factor Receptor-1 Protects After Mouse Liver Transplantation Whereas Host Tumor Necrosis Factor Receptor-1 Promotes Injury

Transplantation, 2006
Tumor necrosis factor (TNF)-alpha is a cytokine with pleiotropic effects on the liver. The predominant hepatic receptor for TNFalpha is TNF receptor-1 (TNFR1). TNFR1 mediates liver injury after ischemia/reperfusion but is also mitogenic during hepatic regeneration.
Lars O, Conzelmann, Mark, Lehnert, Michael, Kremer, Zhi, Zhong, Michael D, Wheeler, John J, Lemasters   +5 more
openaire   +2 more sources

Tumor Necrosis Factor Is Involved in the Appearance of Interleukin-1 Receptor Antagonist in Endotoxemia

Journal of Infectious Diseases, 1994
To assess the role of tumor necrosis factor (TNF) in the appearance of interleukin-1 receptor antagonist (IL-1RA) in endotoxemia, 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 8 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli ...
van der Poll, T., van Deventer, S. J., ten Cate, H., Levi, M. [=Marcel M.], ten Cate, J. W.   +4 more
openaire   +2 more sources

Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2

Chinese Journal of Integrative Medicine, 2011
To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair the intestinal epithelium barrier disruption in Crohn's disease (CD).The CD rat models were established by ...
Yin, Shi, En-Hua, Zhou, Huan-Gan, Wu, Ci-Li, Zhou, Qian-Yao, Wang, Li, Qi   +5 more
openaire   +2 more sources

Ganglioside expression in tissues of mice lacking the tumor necrosis factor receptor 1 [PDF]

Carbohydrate Research, 1999
This study presents a comparative analysis of gangliosides from lymphoid (spleen and thymus) and other tissues (brain, liver, lung, muscle) of C57BL/6 mice homozygous (-/-) and heterozygous (+/-) for the tumor necrosis factor receptor 1 (TNFRp55). Quantitative and qualitative differences in the expression of the lipid-bound N-acetylneuraminic (Neu5Ac ...
Markotić, Anita, Lümen, R., Marušić, Ana, Jonjić, Stipan, Müthing, J.   +4 more
openaire   +3 more sources

Tumor necrosis factor (TNF)-induced cutaneous necrosis is mediated by TNF receptor 1.

Journal of inflammation, 1997
Tumor necrosis factor (TNF) is a central mediator of immune and inflammatory responses. Its activities have been shown to be mediated by two distinct receptors, TNFR1 (p55) and TNFR2 (p75). The cytoplasmic domains of both TNF receptors are unrelated, suggesting that they link to different intracellular signaling pathways.
S, Amar, T E, Van Dyke, H P, Eugster, N, Schultze, P, Koebel, H, Bluethmann   +5 more
openaire   +2 more sources

The Role of Tumor Necrosis Factor Receptor Type 1 in Orthodontic Tooth Movement

Journal of Dental Research, 2007
Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)-α plays an important role, directly or via chemokine release, in osteoclast recruitment and activation. This study aimed to investigate whether the TNF receptor type 1 (p55) influences these events and, consequently, orthodontic tooth ...
I, Andrade, T A, Silva, G A B, Silva, A L, Teixeira, M M, Teixeira   +4 more
openaire   +2 more sources

Cloning and expression of porcine recombinant soluble tumor necrosis factor receptor 1

American Journal of Veterinary Research, 1998
Abstract Objective To clone, sequence, and express porcine recombinant soluble tumor necrosis factor receptor 1 (sTNFR1). Procedure A polymerase chain reaction (PCR)-based library enrichment ...
N, Maroushek Boury, B T, Bosworth, T J, Stabel, M E, Kehrli, M J, Taylor   +4 more
openaire   +2 more sources

Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

Neurology, 1999
We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered.
B G, Weinshenker, D, Hebrink, D M, Wingerchuk, C J, Klein, E, Atkinson, P C, O'Brien, C T, McMurray   +6 more
openaire   +2 more sources

A Humanized Tumor Necrosis Factor Receptor 1 (TNFR1)-specific Antagonistic Antibody for Selective Inhibition of Tumor Necrosis Factor (TNF) Action

Journal of Immunotherapy, 2008
Tumor necrosis factor (TNF) is a recognized pathogenic mediator in a number of chronic and acute inflammatory diseases. Antibodies targeting TNF have significantly improved therapy of chronic inflammatory diseases, in particular rheumatoid arthritis. Despite this success, anti-TNF treatment shows clinical efficacy only in part of the patients and is ...
Roland E, Kontermann, Sabine, Münkel, Jens, Neumeyer, Dafne, Müller, Marcus, Branschädel, Peter, Scheurich, Klaus, Pfizenmaier   +6 more
openaire   +2 more sources

Modulation of colony-stimulating factor-1 receptors on macrophages by tumor necrosis factor.

The Journal of Immunology, 1989
Abstract The effect of murine rTNF-alpha on the binding of human 125I-rCSF-1 to murine thioglycolate-elicited peritoneal exudate macrophages (PEM) was investigated. At 4 degrees C, 125I-CSF-1 binding to PEM was inhibited by preincubation with human rCSF-1, but not by other cytokines.
J H, Shieh, R H, Peterson, D J, Warren, M A, Moore   +3 more
openaire   +2 more sources