Results 61 to 70 of about 34,617,262 (326)

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis*

Journal of Biological Chemistry, 1997
The pivotal discovery that the death proteases caspase 8 (FLICE) and caspase 10 (Mch4/FLICE2) are recruited to the CD-95 and tumor necrosis factor receptor-1 signaling complexes suggested a mechanism used by these cytotoxic receptors to initiate ...
Shimin Hu, C. Vincenz, J. Ni, R. Gentz, V. Dixit   +4 more
semanticscholar   +1 more source

Acute Tumor Necrosis Factor-α-Induced Liver Injury in the Absence of Tumor Necrosis Factor Receptor-Associated Factor 1 Gene Expression [PDF]

The American Journal of Pathology, 2005
Pulmonary and serum levels of tumor necrosis factor-alpha (TNF-alpha), are elevated in many lung diseases, causing local inflammation, fever, and multiorgan, including hepatic, dysfunction. Cellular responses to TNF-alpha are determined by recruitment of specific proteins to intracellular receptor signaling complexes.
Gloria S, Pryhuber, Heidie L, Huyck, Jason M, Roper, Judith, Cornejo, Michael A, O'Reilly, Robert H, Pierce, Erdyni N, Tsitsikov   +6 more
openaire   +2 more sources

Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente [PDF]

, 2001
Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts.
Angulo, A, Ko, M, Britt, William J, Senderowicz, L, Banks, Theresa A, Mira Ko, Chris A Benedict, Benedict, C A, Benedict, Chris A, Ghazal, Peter, Lionel Senderowicz, Ko, Mira, William J Britt, Senderowicz, Lionel, Britt, W J, Carl F Ware, Ware, C F, Banks, T A, Ware, Carl F, Angulo, Ana, Ana Angulo, Theresa A Banks, Peter Ghazal, Ghazal, P   +23 more
core   +1 more source

Evaluation of mRNA Expression Levels of TNFα, TNFR1 and IL1β in Lung Tissue 20 Years after Sulfur-mustard Exposure

Iranian Journal of Allergy, Asthma and Immunology, 2018
Despite many years having passed since exposure to sulfur mustard (SM) gas, there are many exposed subjects who are still suffering from delayed pulmonary complications. The levels of pro-inflammatory cytokines in the lung of these subjects have not been
Marzieh Eghtedardoost, Zuhair Mohammad Hassan, Tooba Ghazanfari, Alireza Sadeghipour, Mostafa Ghanei   +4 more
doaj   +1 more source

The function of TRADD in signaling via tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

Nature Immunology, 2008
The physiological function of the adaptor protein TRADD remains unclear because of the unavailability of a TRADD-deficient animal model. By generating TRADD-deficient mice, we found here that TRADD serves an important function in tumor necrosis factor ...
Yelena L. Pobezinskaya, You-Sun Kim, S. Choksi, M. Morgan, Tao Li, Cheng-Yu Liu, Zheng-Gang Liu   +6 more
semanticscholar   +1 more source

Implications of a local overproduction of tumor necrosis factor-α in complex regional pain syndrome [PDF]

, 2011
Objective. To review the implications of a local overproduction of tumor necrosis factor-α for the pathogenesis and treatment of complex regional pain syndrome. Background.
Walker, S., Drummond, P.D.
core  

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Inhibition of Tumor Necrosis Factor Receptor 1 Signaling by Small Molecules

The FASEB Journal, 2017
Tumor necrosis factor receptor 1 (TNFR1) is a member of the TNFR superfamily which can be activated by binding to one of two cognate ligands, tumor necrosis factor (TNF‐α) or lymphotoxin‐α (LT‐α), via its extracellular domain.
Chih-Hung Lo, Nagamani Vunnam, Andrew K. Lewis, Ting-Lan Chiu, Benjamin E. Brummel, Tory M. Schaaf, Benjamin D. Grant, Prachi Bawaskar, David D. Thomas, J. Sachs   +9 more
semanticscholar   +1 more source

Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis

Journal of Biological Chemistry, 2000
The potent osteoclastogenic agent, tumor necrosis factor-alpha (TNF), exerts its biological effects via two receptors, namely TNF receptors 1 (p55r) and 2 (p75r), each present on osteoclast precursors. Thus, we asked if p55r and p75r differentially impact the osteoclastogenic process.
Y, Abu-Amer, J, Erdmann, L, Alexopoulou, G, Kollias, F P, Ross, S L, Teitelbaum   +5 more
openaire   +2 more sources

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]

, 2005
Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Taylor, DL, Pocock, JM, Jones, F, Kubota, ESFCS   +3 more
core