Results 241 to 250 of about 589,523 (288)

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, EarlyView.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

Rosa roxburghii Tratt. enhances fracture healing through multitarget regulation of osteogenesis and angiogenesis: Integrated network pharmacology and molecular docking analysis. [PDF]

Medicine (Baltimore)
Wu Z, Luo P, Liu H, Xu J, Ying Q, Zhang J, Xuan Z.   +6 more
europepmc   +1 more source

TNFR Pathway-Related Proteins and Recurrent Coronary Artery Disease Events. [PDF]

JACC Adv
Lee J, Bellomo TR, Halford JL, Jemma Cho SM, Koyama S, Dron J, Haidermota S, Ruan Y, Urbut S, Truong B, Patel A, Natarajan P.   +11 more
europepmc   +1 more source

Mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma. [PDF]

World J Gastroenterol
Wan KR, Qian C, Liu LM.
europepmc   +1 more source

Integrated Single-Cell Profiling Reveals TL1A as a Biomarker and Driver of Type 2 Inflammation via Macrophage-Dependent Immunoregulation in Asthma. [PDF]

Research (Wash D C)
Zhang J, Liu X, Qi Q, Pan Y, Zeng R, Qiao C, Xu C, Wang P, Shi S, Wang Y, Liu X, Dong L.   +11 more
europepmc   +1 more source

Combining Cytokine-Related Biomarkers to Better Define Tumor Necrosis Factor-α Antagonist Response in Inflammatory Bowel Disease: An Observational Cohort Study. [PDF]

Clin Transl Gastroenterol
Rooney E, Dela Cruz GR, Ponich T, Gregor JC, Chande N, Beaton MD, Sey M, Khanna R, Kim RB, Wilson A.   +9 more
europepmc   +1 more source

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Estradiol Modulates Tumor Necrosis Factor-Induced Endothelial Inflammation: Role of Tumor Necrosis Factor Receptor 2

Journal of Vascular Research, 2012
The sex hormone estradiol (E₂) appears to mediate both anti-atherogenic and pro-inflammatory effects in premenopausal women, suggesting a complex immunomodulatory role. Tumor necrosis factor (TNF) is a key pro-inflammatory cytokine involved in the pathogenesis of atherosclerosis and other inflammatory diseases. Alterations at the
Subhadeep, Chakrabarti, Sandra T, Davidge   +1 more
openaire   +2 more sources

Function and Regulation of Tumor Necrosis Factor Receptor Type 2

Current Medicinal Chemistry, 2004
TNF is a major proinflammatory cytokine, which exerts its effects through two different receptors known as TNF-R1 and TNF-R2. Whereas TNF-R1 induced signaling pathways have been very well characterized during the past years, TNF-R2 has been much less well studied.
I, Carpentier, B, Coornaert, R, Beyaert
openaire   +2 more sources

Lovastatin Induces Neuroprotection Through Tumor Necrosis Factor Receptor 2 Signaling Pathways

Journal of Alzheimer's Disease, 2008
Statins are widely used as medication to lower cholesterol levels in human patients. In addition, it was recently reported that they also reduce the incidence of stroke and progression of Alzheimer's disease when prophylactically administered. To date there is only limited information available on how statins exert this beneficial effect. In this study
Dolga, Amalia M., Nijholt, Ingrid M., Ostroveanu, Anghelus, ten Bosch, Quirine, Luiten, Paul G. M., Eisel, Ulrich L. M.   +5 more
openaire   +3 more sources