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Characterization of Porcine Tumor Necrosis Factor Receptor 2: Implications for Xenotransplantation
Transplantation Proceedings, 2007Clinical solid organ xenotransplantation is precluded by the strong immune response that results in rejection of pig xenografts in primate models. Innate immunity seems to play a major role in this process. In particular, tumor necrosis factor (TNF), produced by natural killer cells and macrophages, contributes to xenograft rejection by promoting ...
C, Costa, S R, Casinghino, W L, Fodor
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Polymorphic analysis of the high‐affinity tumor necrosis factor receptor 2
Tissue Antigens, 1999The tumor necrosis factor receptor 2 (TNF‐RII, CD120b, TNF‐R p75/80) gene has recently been characterised. It is located on chromosome 1p36.2 and consists of 10 exons and 9 introns. A number of biallelic polymorphisms have been found in exons 4, 6, 9 and 10 based on differences between published sequences.
P, Pantelidis +5 more
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Archives of Oral Biology, 2020
Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 ...
Matić Petrović, Sanja +9 more
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Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 ...
Matić Petrović, Sanja +9 more
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Life Sciences, 2001
Using reverse transcription-polymerase chain reaction (RT-PCR) technique, the messenger RNA (mRNA) for tumor necrosis factor receptor type 2 (TNF-R2, 75/80 kDa) was detected in rat primary astrocytes, with much lower level of expression when compared to that for tumor necrosis factor receptor type 1 (TNF-R1, 55/60 kDa).
Lung, H.L. +4 more
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Using reverse transcription-polymerase chain reaction (RT-PCR) technique, the messenger RNA (mRNA) for tumor necrosis factor receptor type 2 (TNF-R2, 75/80 kDa) was detected in rat primary astrocytes, with much lower level of expression when compared to that for tumor necrosis factor receptor type 1 (TNF-R1, 55/60 kDa).
Lung, H.L. +4 more
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Theriogenology, 2015
Tumor necrosis factor (TNF) alpha likely mediates embryomaternal communication in mammals. In bovine, we have previously found that the uterine fluid of heifers that carried early embryos shows downregulation in the TNF and nuclear factor κB system. In this work, we assessed the expression of TNF and its receptor TNFR2 in the bovine endometrium and ...
E. Correia-Álvarez +11 more
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Tumor necrosis factor (TNF) alpha likely mediates embryomaternal communication in mammals. In bovine, we have previously found that the uterine fluid of heifers that carried early embryos shows downregulation in the TNF and nuclear factor κB system. In this work, we assessed the expression of TNF and its receptor TNFR2 in the bovine endometrium and ...
E. Correia-Álvarez +11 more
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The role of tumor necrosis factor receptor 2 (TNFR2) in EAE
The Journal of Immunology, 2023Abstract Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system which affects over 2 million people worldwide and is the most common neurological disability in young adults. MS is a heterogenous disease characterized by recurrent, remitting and/or progressive neurological deficits, and clinical ...
Maria Montes De Oca Arena +4 more
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Chinese Journal of Integrative Medicine, 2011
To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair the intestinal epithelium barrier disruption in Crohn's disease (CD).The CD rat models were established by ...
Yin, Shi +5 more
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To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair the intestinal epithelium barrier disruption in Crohn's disease (CD).The CD rat models were established by ...
Yin, Shi +5 more
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The Scientific Journal of Al-Azhar Medical Faculty, Girls, 2020
Background Lacking data about tumor necrosis factor receptor (TNFR)-associated factor (TRAF) molecules in human inflammatory reactions with in-vitro studies which demonstrated the involvement of TRAF molecules in the pathogenesis of inflammatory diseases.
Basma E.-S. Risha +3 more
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Background Lacking data about tumor necrosis factor receptor (TNFR)-associated factor (TRAF) molecules in human inflammatory reactions with in-vitro studies which demonstrated the involvement of TRAF molecules in the pathogenesis of inflammatory diseases.
Basma E.-S. Risha +3 more
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Regulation of lymphocyte tumor necrosis factor receptors by IL-2.
The Journal of Immunology, 1989Abstract Activated lymphocytes are known to express TNF receptors. The precise stimuli involved in induction and regulation of these receptors have not been elucidated. Our findings demonstrate that IL-2, alone and in serum-free conditions, can trigger and regulate TNF receptor expression on normal lymphocytes.
L B, Owen-Schaub +3 more
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Tumor Necrosis Factor Receptor 2 Plays a Minor Role for Mycobacterial Immunity
Pathobiology, 2000Tumor necrosis factor (TNF) signalling via the TNF receptor 1 (TNF-R1) is required for host resistance to mycobacterial infection. The role of TNF-R2 in anti-mycobacterial immunity is not known. Therefore, we compared TNF-R1 and TNF-R2 knockout (KO) mice infected with <i>Mycobacterium bovis</i> BCG (10<sup>7</sup> CFU, i.v ...
M, Jacobs +4 more
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