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Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-α in rat primary astrocytes

Life Sciences, 2001
Using reverse transcription-polymerase chain reaction (RT-PCR) technique, the messenger RNA (mRNA) for tumor necrosis factor receptor type 2 (TNF-R2, 75/80 kDa) was detected in rat primary astrocytes, with much lower level of expression when compared to that for tumor necrosis factor receptor type 1 (TNF-R1, 55/60 kDa).
Lung, H.L.   +4 more
openaire   +4 more sources

Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2

Chinese Journal of Integrative Medicine, 2011
To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair the intestinal epithelium barrier disruption in Crohn's disease (CD).The CD rat models were established by ...
Yin, Shi   +5 more
openaire   +2 more sources

Regulation of lymphocyte tumor necrosis factor receptors by IL-2.

The Journal of Immunology, 1989
Abstract Activated lymphocytes are known to express TNF receptors. The precise stimuli involved in induction and regulation of these receptors have not been elucidated. Our findings demonstrate that IL-2, alone and in serum-free conditions, can trigger and regulate TNF receptor expression on normal lymphocytes.
L B, Owen-Schaub   +3 more
openaire   +2 more sources

Tumor Necrosis Factor Receptor 2 Plays a Minor Role for Mycobacterial Immunity

Pathobiology, 2000
Tumor necrosis factor (TNF) signalling via the TNF receptor 1 (TNF-R1) is required for host resistance to mycobacterial infection. The role of TNF-R2 in anti-mycobacterial immunity is not known. Therefore, we compared TNF-R1 and TNF-R2 knockout (KO) mice infected with <i>Mycobacterium bovis</i> BCG (10<sup>7</sup> CFU, i.v ...
M, Jacobs   +4 more
openaire   +2 more sources

Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target

Expert Opinion on Therapeutic Targets, 2019
Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities. TNFR2 has proinflammatory effects too, but it also elicits strong anti-inflammatory activities and has protective effects on oligodendrocytes, cardiomyocytes, and keratinocytes.
Juliane, Medler, Harald, Wajant
openaire   +2 more sources

Determination of Soluble Tumor Necrosis Factor Receptor 2 Produced by Alternative Splicing

2014
Soluble cytokine receptors have proven to be very useful biomarkers in a large variety of diseases, including cancer, infections, and chronic inflammatory diseases. These soluble receptors are produced by proteolytic cleavage or alternative splicing. Several cytokine receptors including tumor necrosis factor receptor 2 (TNFR2) can be generated by both ...
Xavier, Romero   +2 more
openaire   +2 more sources

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