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Characterization of Porcine Tumor Necrosis Factor Receptor 2: Implications for Xenotransplantation

Transplantation Proceedings, 2007
Clinical solid organ xenotransplantation is precluded by the strong immune response that results in rejection of pig xenografts in primate models. Innate immunity seems to play a major role in this process. In particular, tumor necrosis factor (TNF), produced by natural killer cells and macrophages, contributes to xenograft rejection by promoting ...
C, Costa, S R, Casinghino, W L, Fodor
openaire   +2 more sources

Polymorphic analysis of the high‐affinity tumor necrosis factor receptor 2

Tissue Antigens, 1999
The tumor necrosis factor receptor 2 (TNF‐RII, CD120b, TNF‐R p75/80) gene has recently been characterised. It is located on chromosome 1p36.2 and consists of 10 exons and 9 introns. A number of biallelic polymorphisms have been found in exons 4, 6, 9 and 10 based on differences between published sequences.
P, Pantelidis   +5 more
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The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population

Archives of Oral Biology, 2020
Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 ...
Matić Petrović, Sanja   +9 more
openaire   +5 more sources

Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-α in rat primary astrocytes

Life Sciences, 2001
Using reverse transcription-polymerase chain reaction (RT-PCR) technique, the messenger RNA (mRNA) for tumor necrosis factor receptor type 2 (TNF-R2, 75/80 kDa) was detected in rat primary astrocytes, with much lower level of expression when compared to that for tumor necrosis factor receptor type 1 (TNF-R1, 55/60 kDa).
Lung, H.L.   +4 more
openaire   +4 more sources

Early embryonic and endometrial regulation of tumor necrosis factor and tumor necrosis factor receptor 2 in the cattle uterus

Theriogenology, 2015
Tumor necrosis factor (TNF) alpha likely mediates embryomaternal communication in mammals. In bovine, we have previously found that the uterine fluid of heifers that carried early embryos shows downregulation in the TNF and nuclear factor κB system. In this work, we assessed the expression of TNF and its receptor TNFR2 in the bovine endometrium and ...
E. Correia-Álvarez   +11 more
openaire   +3 more sources

The role of tumor necrosis factor receptor 2 (TNFR2) in EAE

The Journal of Immunology, 2023
Abstract Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system which affects over 2 million people worldwide and is the most common neurological disability in young adults. MS is a heterogenous disease characterized by recurrent, remitting and/or progressive neurological deficits, and clinical ...
Maria Montes De Oca Arena   +4 more
openaire   +1 more source

Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2

Chinese Journal of Integrative Medicine, 2011
To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair the intestinal epithelium barrier disruption in Crohn's disease (CD).The CD rat models were established by ...
Yin, Shi   +5 more
openaire   +2 more sources

Expression of interleukin-6 receptor, tumor necrosis factor receptor-associated factor-2, and tumor necrosis factor receptor-associated factor-5 as new reliable markers in psoriasis vulgaris

The Scientific Journal of Al-Azhar Medical Faculty, Girls, 2020
Background Lacking data about tumor necrosis factor receptor (TNFR)-associated factor (TRAF) molecules in human inflammatory reactions with in-vitro studies which demonstrated the involvement of TRAF molecules in the pathogenesis of inflammatory diseases.
Basma E.-S. Risha   +3 more
openaire   +1 more source

Regulation of lymphocyte tumor necrosis factor receptors by IL-2.

The Journal of Immunology, 1989
Abstract Activated lymphocytes are known to express TNF receptors. The precise stimuli involved in induction and regulation of these receptors have not been elucidated. Our findings demonstrate that IL-2, alone and in serum-free conditions, can trigger and regulate TNF receptor expression on normal lymphocytes.
L B, Owen-Schaub   +3 more
openaire   +2 more sources

Tumor Necrosis Factor Receptor 2 Plays a Minor Role for Mycobacterial Immunity

Pathobiology, 2000
Tumor necrosis factor (TNF) signalling via the TNF receptor 1 (TNF-R1) is required for host resistance to mycobacterial infection. The role of TNF-R2 in anti-mycobacterial immunity is not known. Therefore, we compared TNF-R1 and TNF-R2 knockout (KO) mice infected with <i>Mycobacterium bovis</i> BCG (10<sup>7</sup> CFU, i.v ...
M, Jacobs   +4 more
openaire   +2 more sources

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