Results 91 to 100 of about 2,022,996 (246)

Personal neoantigen cancer vaccines: The momentum builds [PDF]

, 2014
Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient’s tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer.
Wu, Catherine, Fritsch, Edward F, Hacohen, Nir   +2 more
core   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Neoantigen-reactive T cells exhibit effective anti-tumor activity against colorectal cancer

, 2021
Neoantigens play a crucial role in cancer immunotherapy. However, the effectiveness and safety of neoantigen-based immunotherapies in patients with colorectal cancer (CRC), particularly in the Chinese population, have not been well studied.
Xiaoping Su, Zhanxiong Xue, Weihong Sun, Limiao Lin, Zhenzhai Cai, Jing Zhang, Hejie Yu, Xiangyang Xue, Yaojun Yu, Haiping Song, Yuesheng Zhu, Yangyang Teng, Xian Shen, Leyi Ni   +13 more
core   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

UNPACKING THE ROLE OF NEOANTIGENS AND TUMOR MUTATIONAL BURDEN IN CANCER IMMUNOTHERAPY

Cancer immunotherapy has revolutionized oncology by leveraging the immune system to combat tumors. Among various biomarkers, neoantigens and tumor mutational burden (TMB) have emerged as critical factors in tailoring personalized treatments. Neoantigens are tumor-specific peptides displayed on cancer cell surfaces, derived from somatic mutations ...
openaire   +1 more source

Figure 6 from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<p>Per splice junction normalized SA for responders compared with baseline samples. The SA averaged across samples for the subset of splice junctions derived from the top 20 genes with the highest SA per sample. The black horizontal line is the median SA for baseline samples.
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Figure 1 from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<p>SpliceMutr pipeline. The SpliceMutr pipeline uses RNA-seq data from two groups of samples and evaluates the changes in SA between them. In this example, the alternative splicing analysis compares tumor and normal RNA-seq samples. The pipeline performs splicing-aware alignment, gene expression quantification, and HLA genotyping.
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source