Results 101 to 110 of about 2,022,996 (246)

Figure 5 from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<p>Per-patient SA of ICI-treated patients with melanoma per treatment arm and response type after treatment. <b>A,</b> The per-patient pseudo purity compared with the mean SA averaged across genes by the response for all treatment arms. Kendall Tau test.
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Supplementary Data from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<p>The supplementary figures file</p>
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Data from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<div>Abstract<p>Aberrant alternative splicing can generate neoantigens, which can themselves stimulate immune responses and surveillance. Previous methods for quantifying splicing-derived neoantigens are limited by independent references and potential batch effects.
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

Figure 2 from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<p>Comparison of predicted splicing antigens from SpliceMutr to proteomics datasets. <b>A,</b> The log₁₀-transformed total number of MHC-binding kmers found with and without reference kmer filtering in all samples of the breast cancer TCGA cohort (BRCA).
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

The role of neoantigen in immune checkpoint blockade therapy

, 2018
Immune checkpoint inhibitor induces tumor rejection by activated host immune system. The anti-tumor immune response consists of capture, presentation, recognition of neoantigen, as well as subsequent killing of tumor cell.
Ming Yi, Weiheng Zhao, Shuang Qin, Qian Chu, Kongming Wu, Shengnan Yu   +5 more
core   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Personal Neoantigen Vaccines Induce Persistent Neoantigen-Specific Memory T Cell Responses and Epitope Spreading in High-Risk Melanoma Patients

, 2020
Cancer vaccines have long been envisioned as an effective approach to generate, amplify and diversify T cell responses against tumors. The recent availability of next-generation sequencing (NGS) has enabled the comprehensive identification of mutations ...
Leet, Donna
core   +2 more sources

Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer

Biology Direct
Background Tumor Mutational Burden (TMB) have emerged as pivotal predictive biomarkers in determining prognosis and response to immunotherapy in colorectal cancer (CRC) patients.
Yangyang Fang, Tianmei Fu, Qian Zhang, Ziqing Xiong, Kuai Yu, Aiping Le   +5 more
doaj   +1 more source