Results 241 to 250 of about 1,772,736 (291)
Some of the next articles are maybe not open access.
Annual Review of Biochemistry, 1993
THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
openaire +2 more sources
THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
openaire +2 more sources
The Biomedical & Life Sciences Collection, 2016
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
openaire +1 more source
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
openaire +1 more source
Tumor suppressor genes in urologic tumors
Urology, 1993During the last decade remarkable progress has been made in our understanding of the malignant phenotype. There is evidence that a series of genetic changes are involved in the conversion of a normal cell to a malignant one. These changes have been directly identified with mutations in various genes usually involved in cell growth and proliferation ...
J M, Wolff, F K, Habib
openaire +2 more sources
BioEssays, 1990
AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
openaire +2 more sources
AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
openaire +2 more sources
BAP1tism of a Tumor Suppressor
Clinical Cancer Research, 2012Abstract Driving cancer cells into a more differentiated state is a rational therapeutic approach. Primary uveal melanoma cells with a propensity to metastasize have less-differentiated features than their less aggressive counterparts.
openaire +2 more sources
Remodeling of the ARID1A tumor suppressor
Cancer Letters, 2020In recent years, AT-rich interactive domain-containing protein 1A (ARID1A) has been widely accepted as a bona fide tumor suppressor due to its essential role in preventing tumorigenesis and tumor progression in both mouse and human contexts. ARID1A shows high mutation frequencies in both cancers and preneoplastic lesions.
Qingyu Luo, Xiaowei Wu, Zhihua Liu
openaire +2 more sources
Current Opinion in Genetics & Development, 2000
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
openaire +2 more sources
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
openaire +2 more sources
SIRT1: Tumor promoter or tumor suppressor?
Medical Hypotheses, 2006Over the past decade, an intensive research on the basic biology of aging has identified individual genes either directly or indirectly involved in regulating the aging process in various model organisms. This allows us to garner all the information available from studies of model organisms and to apply them to better understand aging and cancer in ...
openaire +2 more sources
Dormant Tumor-Suppressor Pathways in Tumors
American Journal of Respiratory Cell and Molecular Biology, 1999It was initially thought that activation of a single oncogene such as Ras would result in tumorigenesis; however, this conclusion was based on studies in which immortalized cells were used as the target cells in transformation assays (1). Thus it was significant when in 1983 Newbold and Overell reported that an activated Ras gene failed to transform ...
openaire +2 more sources
Annual Review of Genetics, 1990
INTRODUCTION . . . , ... ,", .. ", .... ,',', .... ", ..... , ...... " .... ,', .... ,' .. """, ... "" ....... '" 616 SOMATIC CELL HYBRID STUDIES . . . . . . . ... . . .. . . . . . . . . . . , 616 Specific Chromos,?me are Asso iated with Control of Tumorlgemc ExpressIOn . . . .
openaire +2 more sources
INTRODUCTION . . . , ... ,", .. ", .... ,',', .... ", ..... , ...... " .... ,', .... ,' .. """, ... "" ....... '" 616 SOMATIC CELL HYBRID STUDIES . . . . . . . ... . . .. . . . . . . . . . . , 616 Specific Chromos,?me are Asso iated with Control of Tumorlgemc ExpressIOn . . . .
openaire +2 more sources