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Current Opinion in Genetics & Development, 2005
OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors.
Chun-Ming, Chen, Richard R, Behringer
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OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors.
Chun-Ming, Chen, Richard R, Behringer
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Oncogenes and tumor suppressor genes
1993Cancer-associated genes generally can be divided into ‘dominant’ acting protooncogenes/oncogenes and ‘recessive’ tumor suppressor genes. Most simply defined, protooncogenes are identified by a gain of function as mutational damage occurs, whereas tumor suppressor genes contribute to cancer by a loss of function. However, the pace of science leads us to
E, Liu, B, Weissman
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1993
L A, Donehower, A, Bradley
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L A, Donehower, A, Bradley
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Brain and other central nervous system tumor statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Rebecca L. Siegel +2 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Heather Parsons +2 more
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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
Cancer Cell, 2020Robert N Eisenman +2 more
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