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cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcoma
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Neuron, 1991
For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular ...
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For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular ...
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Current Opinion in Genetics & Development, 1994
The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
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The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
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Current Opinion in Genetics & Development, 2000
Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
Tracey L. Plank, Elizabeth Petri Henske
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Although tumor suppressor genes continue to be discovered, the most recent advances have been made in attributing new and exciting functions to existing ones - such as the apparent role of VHL as a regulator of proteolysis. Great insights have also come from piecing genes together into pathways and networks. For instance the discovery that cyclin D1 is
Tracey L. Plank, Elizabeth Petri Henske
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Current Opinion in Genetics & Development, 2005
OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors.
Chun-Ming, Chen, Richard R, Behringer
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OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors.
Chun-Ming, Chen, Richard R, Behringer
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Murine tumor suppressor models
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998Tumor suppressor genes have been shown to be necessary for proper maintenance of cell growth control. Inactivation of these genes in the germline of humans is linked to inherited cancer predisposition. Moreover, sporadically arising human tumors often have somatic mutations in tumor suppressor genes. During the past few years, advances in molecular and
S, Venkatachalam, L A, Donehower
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The Biomedical & Life Sciences Collection, 2016
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
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A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
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BioEssays, 1990
AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
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AbstractThe retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting ...
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Annual Review of Biochemistry, 1993
THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
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THE ORIGINS OF THE CONCEPT OF TUMOR SUPPRESSOR GENES . . . . . . . 623 THE PROPERTIES OF ONCOGENES AND TUMOR SUPPRESSOR GENES . . 627 THE ONCOGENES OF THE DNA TUMOR VIRUSES TARGET THE MAJOR CELLULAR TUMOR SUPPRESSOR GENES 629 THE RETINOBLASTOMA SUSCEPTIBILITY GENE AND PROTEIN ........
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