Results 211 to 220 of about 308,123 (261)

Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment. [PDF]

Cancer Res
Ferreira S, Flowers BM, Choi WY, Farina-Morillas M, Gatto A, Bhattacharyya S, Boross G, Hassan G, Mulligan AS, Vogel H, Wood LD, Weaver VM, Winslow MM, Petrov DA, Sherman MH, Choi HY, Hayes DN, Aguirre AJ, Seoane JA, Attardi LD.   +19 more
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Fundamentals and emerging frontiers in p53-targeted drug development. [PDF]

Biochem Biophys Rep
Long HD, Zhang N, Wang WE, Ma YS, Liu FX, Chen ZY, Lu CN, Wang XF, Han N, Cai YF, Yang C, Tang XM, Yu H, Jiang H, Fu D, Chu KJ, Wu WG.   +16 more
europepmc   +1 more source

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Tumor suppressor C-RASSF proteins

Cellular and Molecular Life Sciences, 2018
Human genome has ten genes that are collectedly called Ras association domain family (RASSF). RASSF is composed of two subclasses, C-RASSF and N-RASSF. Both N-RASSF and C-RASSF encode Ras association domain-containing proteins and are frequently suppressed by DNA hypermethylation in human cancers. However, C-RASSF and N-RASSF are quite different. Six C-
Yutaka Hata, Hiroaki Iwasa, Hata Yutaka   +2 more
exaly   +3 more sources

Oncoproteins and Tumor Suppressor Proteins in Congenital Sacrococcygeal Teratomas

Pediatric Pathology & Laboratory Medicine: Journal of the Society for Pediatric Pathology, Affiliated With the International Paediatric Pathology Association, 1997
Congenital sacrococcygeal teratoma (SCT) is the most common germ cell tumor of infancy and childhood with a female preponderance. Most SCTs are diagnosed at birth, are benign, and consist of fully differentiated, mature tissues. Tumorigenesis of SCTs remains poorly understood.
Spomenka Manojlovic, Krešimir Pavelić, Reno Hrašćan   +2 more
exaly   +4 more sources

Cell Adhesion Proteins As Tumor Suppressors

The Journal of Urology, 2002
We summarize recent progress on the role of cell adhesion molecules in biology and discuss the potential application of cell adhesion molecules for managing urological cancer.We comprehensively reviewed the literature from 1982 to 2001, including peer reviewed publications and recent abstracts from national meetings, relevant to cell adhesion molecules
Takatsugu, Okegawa, Yingming, Li, Rey-Chen, Pong, Jer-Tsong, Hsieh   +3 more
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The Petinoblastoma Tumor Suppressor Protein

1994
Publisher Summary The studies of retinoblastoma (RB) have been driven by three hypotheses: (1) RB is the suppressor of retinoblastoma and possibly the other types of cancer, (2) RB inhibits proliferation by preventing the transcription of genes critical for cell cycle progression, and (3) the inhibitory function of RB can be neutralized by ...
J Y, Wang, E S, Knudsen, P J, Welch
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The Tumor Suppressor Protein p16INK4a

Experimental Cell Research, 1997
The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer.
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The retinoblastoma tumor suppressor protein

Current Opinion in Genetics & Development, 1995
Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/
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