Results 221 to 230 of about 302,791 (267)
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The Tumor Suppressor Protein p16INK4a
Experimental Cell Research, 1997The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer.
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2001
The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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The p53 protein was originally identified during the late 1970s, by several independent groups, as a novel cellular protein that was tightly associated with the large T antigen in cells transformed by simian virus-40 (SV40) (1–3). Although originally thought to function as an oncogene, isolation of the wild-type (wt) gene encoding p53 led to the ...
Margaret Ashcroft, Karen H. Vousden
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The von Hippel–Lindau tumor suppressor protein
Current Opinion in Genetics & Development, 2001The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen.
M, Ivan, W G, Kaelin
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Stress-activated protein kinases?tumor suppressors or tumor initiators?
Seminars in Cancer Biology, 2004The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity.
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Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein
Cancer Research, 2005Abstract Programmed cell death 4 (Pdcd4) is a tumor suppressor protein that interacts with eukaryotic initiation factor 4A and inhibits protein synthesis. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)–responsive promoters by c-Jun.
PALAMARCHUK A. +5 more
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The P53 Tumor Suppressor Protein
1995In response to damaged DNA, mammalian cell growth is arrested at cell cycle checkpoints in Gl, near the border of S phase, or in G2, before mitosis (Murray, 1992; Hunter, 1993; Weinert and Lydall, 1993). In some circumstances, DNA damage initiates apoptosis, a program that results in cell death.
Ettore Appella +7 more
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p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs
Veterinary Pathology, 1996Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry.
J E, Sagartz +5 more
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Functional dissection of p53 tumor suppressor protein
1997Publisher Summary This chapter discusses the functional dissection of p53 tumor suppressor protein. The p53 tumor suppressor protein plays a pivotal role in tumor suppression and is mutated very frequently in many forms of human cancer. Stress signals such as DNA damage and hypoxia cause the induction and activation of p53 in normal cells with the ...
L, Jayaraman, E, Freulich, C, Prives
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Protein Partners of the BRCA1 Tumor Suppressor
Breast Disease, 1998The primary amino acid sequence of BRCA1 offers few clues about the mechanism by which it suppresses tumor formation in normal breast and ovarian tissues. In an effort to unravel its biological functions, investigators have sought to identify the proteins that interact with BRCA1 in vivo.
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The Retinoblastoma Protein: More than a Tumor Suppressor
Annual Review of Cell Biology, 1994REGULATION OF RB DURING CELL CYCLE PROGRESSION AND DIFFERENTIATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Modification of Rb by Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Gl Arrest by Overexpression of Rb . . . . . . . . . . . . . . . . . . . . . . . . .
D J, Riley, E Y, Lee, W H, Lee
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