Results 241 to 250 of about 2,989,296 (301)

Decoding Post-Transcriptional Networks Governing the Melanoma Extracellular Matrix. [PDF]

Cancers (Basel)
Katsoulieris EN, Ioannou P, Afratis NA.
europepmc   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

The Role of Alternative Splicing in Lung Cancer: Mechanisms, Regulators, and Therapeutic Implications. [PDF]

Int J Mol Sci
Shang L, Wang N, Liu Q, Chen L, Liu H.
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

PDLIM2 acts as a central regulator of ubiquitination, immune signaling, and mitochondrial metabolism in lung cancer suppression (Review). [PDF]

Int J Oncol
Chuang TH, Guo JH, Yang JX, Tseng JC, Wang HJ, Lai CY.   +5 more
europepmc   +1 more source

Surface Functionalization Modulates Collective Cell Behavior Near Topological Defects Induced by Topographical Patterning

Advanced Materials Interfaces, EarlyView.
Strongly adhered cells align with concentric circular ridges and exhibit predominantly tangential motion, whereas weakly adhered cells fail to follow topographical guidance and display enhanced radial inward motion. ABSTRACT Living cells establish long‐range orientational order through collective alignment, giving rise to topological defects whose ...
Prasoon Awasthi, Aniruddh Murali, Ellen Juel Pørtner, Adam Cohen Simonsen, Francesca Serra   +4 more
wiley   +1 more source

The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options. [PDF]

Mol Cancer
Luo C, Xia N, Hui SY, Wong US, Tsang JY, Hu H, Tsang CM, Lo KW, Sun P, Shao M, Alahari SK, Kang W, Tse GM, Guo D.   +13 more
europepmc   +1 more source

Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells. [PDF]

Oncol Rep
Ahn SH, Bhutta ZA, Na H, Lee HK, Choi KC.   +4 more
europepmc   +1 more source

The Role of Autophagy in Cancer Evolution and Prognosis, Highlighting Its Role in PCa and Its Interaction with Apoptosis and Epigenetic Regulation by miRNAs. [PDF]

Med Sci (Basel)
Kurkiewicz M, Moździerz A, Rzepecka-Stojko A, Stojko J.   +3 more
europepmc   +1 more source