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Mechanical load as an endogenous tumor suppressor: Nesprin-2-mediated mechanotransduction reshapes the cancer epigenome. [PDF]
Signal Transduct Target TherPapavassiliou KA, Papavassiliou AG.
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XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review). [PDF]
Int J Mol MedChen Z +6 more
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TRIM28-Derived Peptide Exerts Anti-Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers. [PDF]
Adv Sci (Weinh)Wei Q +10 more
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Tumor suppressor C-RASSF proteins
Cellular and Molecular Life Sciences, 2018Human genome has ten genes that are collectedly called Ras association domain family (RASSF). RASSF is composed of two subclasses, C-RASSF and N-RASSF. Both N-RASSF and C-RASSF encode Ras association domain-containing proteins and are frequently suppressed by DNA hypermethylation in human cancers. However, C-RASSF and N-RASSF are quite different. Six C-
Yutaka Hata, Hiroaki Iwasa
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Oncoproteins and Tumor Suppressor Proteins in Congenital Sacrococcygeal Teratomas
Pediatric Pathology & Laboratory Medicine: Journal of the Society for Pediatric Pathology, Affiliated With the International Paediatric Pathology Association, 1997Congenital sacrococcygeal teratoma (SCT) is the most common germ cell tumor of infancy and childhood with a female preponderance. Most SCTs are diagnosed at birth, are benign, and consist of fully differentiated, mature tissues. Tumorigenesis of SCTs remains poorly understood.
Spomenka Manojlovic +2 more
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Cell Adhesion Proteins As Tumor Suppressors
The Journal of Urology, 2002We summarize recent progress on the role of cell adhesion molecules in biology and discuss the potential application of cell adhesion molecules for managing urological cancer.We comprehensively reviewed the literature from 1982 to 2001, including peer reviewed publications and recent abstracts from national meetings, relevant to cell adhesion molecules
Takatsugu, Okegawa +3 more
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The Petinoblastoma Tumor Suppressor Protein
1994Publisher Summary The studies of retinoblastoma (RB) have been driven by three hypotheses: (1) RB is the suppressor of retinoblastoma and possibly the other types of cancer, (2) RB inhibits proliferation by preventing the transcription of genes critical for cell cycle progression, and (3) the inhibitory function of RB can be neutralized by ...
J Y, Wang, E S, Knudsen, P J, Welch
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The retinoblastoma tumor suppressor protein
Current Opinion in Genetics & Development, 1995Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/
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The Tumor Suppressor Protein p16INK4a
Experimental Cell Research, 1997The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer.
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Protein Partners of the BRCA1 Tumor Suppressor
Breast Disease, 1998The primary amino acid sequence of BRCA1 offers few clues about the mechanism by which it suppresses tumor formation in normal breast and ovarian tissues. In an effort to unravel its biological functions, investigators have sought to identify the proteins that interact with BRCA1 in vivo.
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