Results 231 to 240 of about 308,123 (261)

The Retinoblastoma Protein: More than a Tumor Suppressor

Annual Review of Cell Biology, 1994
REGULATION OF RB DURING CELL CYCLE PROGRESSION AND DIFFERENTIATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Modification of Rb by Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Gl Arrest by Overexpression of Rb . . . . . . . . . . . . . . . . . . . . . . . . .
D J, Riley, E Y, Lee, W H, Lee
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Interaction of Tumor Suppressor p53 with DNA and Proteins

Current Pharmaceutical Biotechnology, 2010
p53, a tumor suppressor and a transcription factor, binds DNA in a sequence-specific manner. In more than half of human cancers, p53 has been found to be mutated with the loss of DNA-binding ability. In this review, we focus on the sensitive detection of interaction of tumor suppressor p53 with double-stranded DNA bearing the consensus sequence and ...
Jianxiu, Wang, Julei, Yang
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Stress-activated protein kinases?tumor suppressors or tumor initiators?

Seminars in Cancer Biology, 2004
The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity.
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Functional dissection of p53 tumor suppressor protein

1997
Publisher Summary This chapter discusses the functional dissection of p53 tumor suppressor protein. The p53 tumor suppressor protein plays a pivotal role in tumor suppression and is mutated very frequently in many forms of human cancer. Stress signals such as DNA damage and hypoxia cause the induction and activation of p53 in normal cells with the ...
L, Jayaraman, E, Freulich, C, Prives
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Inactivation of Tumor Suppressor Proteins in Lung Cancer

American Journal of Respiratory Cell and Molecular Biology, 1996
Abstract It had been thought that the central molecular event in the malignant transformation of a cell is the mutation of certain oncogenes-and the resultant dysregulated activation of their encoded proteins. During the past decade, however, it has become clear that alteration of the activity of the protein products of tumor ...
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p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs

Veterinary Pathology, 1996
Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry.
J E, Sagartz, W L, Bodley, R M, Gamblin, C G, Couto, L A, Tierney, C C, Capen   +5 more
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Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

Cancer Research, 2005
Abstract Programmed cell death 4 (Pdcd4) is a tumor suppressor protein that interacts with eukaryotic initiation factor 4A and inhibits protein synthesis. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)–responsive promoters by c-Jun.
PALAMARCHUK A., EFANOV A., MAXIMOV V., AQEILAN R. I., CROCE, Carlo Maria, PEKARSKY Y.   +5 more
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Interaction of the Tumor Suppressor p53 With Replication Protein A.

1995
Abstract : The DNA replication factor RPA physically associates with the tumor suppressor protein p53, an interaction that could be important for the function of both these proteins in normal and cancer cells. Using two mutant forms of p53 with the desired property of not binding RPA we have demonstrated that RPA binding is not required for growth ...
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Regulation of the p53 tumor suppressor by ribosomal proteins

2009
The capacity to detect and appropriately respond to many different stresses that interfere with functional homeostasis is essential for organismal survival. Recent evidence suggests that the nucleolus, the site of ribosome biogenesis, plays a critical role in sensing and responding to many external and internal stresses.
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Oncogenes and tumor suppressor genes

Ca-A Cancer Journal for Clinicians, 1994
Robert A Weinberg
exaly