Results 231 to 240 of about 302,791 (267)
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Cytoskeletal and adhesion proteins as tumor suppressors
Current Opinion in Cell Biology, 1997In the past year, significant progress has been made in the attempt to understand the molecular mechanisms underlying signaling that is induced by cell-cell and cell-extracellular-matrix adhesion and that involves the cytoskeleton. In particular, molecules of the cytoplasmic plaques of cell-cell junctions have been shown to complex with transcription ...
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LKB1 tumor suppressor protein: PARtaker in cell polarity
Trends in Cell Biology, 2004The LKB1 (also called serine/threonine kinase 11) tumor suppressor gene was cloned in 1998 by linkage analysis of Peutz-Jeghers cancer syndrome patients. Mammalian LKB1 has been implicated as a regulator of multiple biological processes and signaling pathways, including the control of cell-cycle arrest, p53-mediated apoptosis, Wnt signaling ...
Baas, A.F., Smit, L., Clevers, J.C.
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Posttranslational Regulation of p53 Tumor Suppressor Protein Function
Critical Reviews™ in Oncogenesis, 1994Alteration of the p53 gene by deletion and mutation is the most common denominator yet identified among human cancers (Hollstein et al., 1991; Caron de Fromental and Soussi, 1992). The involvement of the p53 gene in such a broad scope of human cancers warrants further investigation into its mechanism of action in regulating cell growth.
S A, Maxwell, J A, Roth
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Activation of the p53 tumor suppressor protein
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2002The p53 tumor suppressor gene plays an important role in preventing cancer development, by arresting or killing potential tumor cells. Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full ...
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Tumor suppressor role of protein 4.1B/DAL-1
Cellular and Molecular Life Sciences, 2014Protein 4.1B/DAL-1 is a membrane skeletal protein that belongs to the protein 4.1 family. Protein 4.1B/DAL-1 is localized to sites of cell-cell contact and functions as an adapter protein, linking the plasma membrane to the cytoskeleton or associated cytoplasmic signaling effectors and facilitating their activities in various pathways. Protein 4.1B/DAL-
Zi, Wang +7 more
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New roles for the RB tumor suppressor protein
Current Opinion in Genetics & Development, 2004For a gene whose existence was first postulated in 1971, was cloned in 1986 and whose functions have been extensively characterized ever since, you might be inclined to think there was not much new to report regarding the retinoblastoma tumor suppressor gene (RB)--but you would be wrong to make such an assumption.
Huiping, Liu +4 more
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ONCOPROTEINS AND TUMOR SUPPRESSOR PROTEINS IN CONGENITAL SACROCOCCYGEAL TERATOMAS
Pediatric Pathology & Laboratory Medicine, 1997Congenital sacrococcygeal teratoma (SCT) is the most common germ cell tumor of infancy and childhood with a female preponderance. Most SCTs are diagnosed at birth, are benign, and consist of fully differentiated, mature tissues. Tumorigenesis of SCTs remains poorly understood.
Krušlin, Božidar +3 more
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Prohibitin: Mitochondrial Tumor Suppressor Protein
1998The prohibitin story begins with the development of an assay for the detection of mRNAs that could inhibit the initiation of DNA synthesis.1’2 Messenger RNAs were tested by microinjecting them into individual human diploid fibroblasts that had been growth-arrested by serum restriction.
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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