Results 71 to 80 of about 308,123 (261)

Parkin induces apoptotic cell death in TNF-α-treated cervical cancer cells [PDF]

BMB Reports, 2012
Many malignant tumors become resistant to tumor necrosisfactor-alpha (TNF-α)-induced cell death during carcinogenesis.In the present study, we examined whether parkin acts as atumor suppressor in HeLa cells, a human cervical cancer cellline resistant to ...
Kyunghong Lee#, Min Ho Lee#, Yeo Wool Kang, Ki-Jong Rhee, Tae Ue Kim & Yoon Suk Kim*
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Clinical seizure features and EEG pattern in patients with anti-leucine-rich glioma-inactivated 1 antibody-associated encephalitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Objective To summarize clinical seizures and electroencephalography (EEG) characteristics of patients with anti ? leucine ? rich glioma ? inactivated 1 (LGI1) antibody ? associated encephalitis.
Qiang LU, Hong-zhi GUAN, Qing LIU, Yan HUANG, Li-ri JIN, Xiang-qin ZHOU, Li-ying CUI   +6 more
doaj   +1 more source

[Tumor suppressors--genes and proteins].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1998
Cancer is generally understood to be a genetic disease in the sense that somatic mutations are the cause of tumour initiation and development. Our knowledge of cancer-associated genes and gene products has evolved mainly over the past 20 years. The identification and characterization of tumour suppressor genes (TSGs) as normal growth-inhibiting or ...
R A, Lothe, H K, Blomhoff
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

Neoplasia: An International Journal for Oncology Research, 2015
Phosphatase and tensin homologue (PTEN), one of the well-characterized tumor suppressor proteins, counteracts the phosphatidylinositol 3-kinase-AKT pathway through its unique lipid phosphatase activity. The functions of PTEN are regulated by a variety of
Makoto Nakakido, Zhenzhong Deng, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto   +5 more
doaj   +1 more source

Aberrant Expression of Tumor Suppressor Proteins in the Ewing Family of Tumors

Archives of Pathology & Laboratory Medicine, 2001
Abstract Background. —Deregulation of tumor suppressor gene function and abrogation of cell cycle control are common features of malignant neoplasms, but corresponding data on Ewing sarcomas and primitive neuroectodermal tumors are relatively scarce.
A, Maitra, H, Roberts, A G, Weinberg, J, Geradts   +3 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)

Heliyon
Ubiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival.
Seema Zadi, Sumaira Javaid, Atia-tul-Wahab, Humaira Zafar, Muhammad Awais, Innokentiy Maslennikov, M. Iqbal Choudhary   +6 more
doaj   +1 more source