Results 81 to 90 of about 2,989,296 (301)

The role of polyhomeotic in polycomb group-mediated regulation of the tumour suppressor P16INK4A [PDF]

, 2010
The INK4A tumour suppressor gene is negatively regulated by the Polycomb Group (PcG) complexes, which plays an important role in stem cell- and cancer biology.
de Breed, L.A.
core  

Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2010 Patani.Background: Ubiquitin modification of proteins influences cellular processes relevant to carcinogenesis.
Jiang, W, Newbold, R, Kefah Mokbel, Patani, Neill, Neill Patani, Mokbel, K, Robert Newbold, Jiang, Wen Guo, Newbold, Robert, Patani, N, Wen Jiang, Mokbel, Kefah   +11 more
core   +1 more source

Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study

Cancer Medicine
Background and Objective To explore the association between protein quantitative trait loci (pQTL‐SNPs) and the risk of LUAD. Methods “Blood +” high depth blood proteomics analysis was performed on plasma from female LUAD patients and female healthy ...
Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu   +18 more
doaj   +1 more source

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein [PDF]

Science, 1995
Germline mutations in the von Hippel-Lindau tumor suppressor gene ( VHL ) predispose individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central nervous system, and pheochromocytoma.
Duan, D., Pause, A., Burgess, W., Aso, T., Chen, D., Garrett, K., Conaway, R., Conaway, J., Linehan, W., Klausner, R.   +9 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Elucidating the role of the tumor suppressor Protein Phoshatase 2A in Chronic Myeloid Leukemia. [PDF]

, 2010
Protein phosphatase-2A (PP2A) is one of the major cellular serine-threonine phosphatases and is involved in the regulation of cell homeostasis through the negative regulation of signaling pathways initiated by protein kinases.
Neviani, Paolo
core  

The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. [PDF]

PLoS ONE, 2013
p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells.
Peiyuan Jia, Yu Zhao, Shaoping Wu, Junhua Wu, Shan Gao, Ying Tong, Yuxia Wang   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Targeting Akt Signaling Pathway in Cancer: Molecular Mechanisms and Advances in Therapeutic Interventions

Frontiers in Bioscience-Landmark
The Akt/PKB (protein kinase B) is a major transducer of the phosphoinositide 3-kinase (PI3K) signaling axis, regulating key cellular processes such as growth, proliferation, apoptosis, survival, and migration in both normal and cancer cells.
Premila D. Leiphrakpam, Rishi Batra, Laura Tenner, Chandrakanth Are   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source