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Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice. [PDF]
, 2015 UnlabelledPeritoneal disseminated cancer is highly treatment resistant. We here report the efficacy of intraperitoneal (i.p.) administration of tumor-targeting Salmonella typhimurium A1-R in a nude mouse model of disseminated human ovarian cancer.
Bouvet, Michael +12 more
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Targeting Tumors Using Peptides [PDF]
Molecules, 2020 To penetrate solid tumors, low molecular weight (Mw < 10 KDa) compounds have an edge over antibodies: their higher penetration because of their small size. Because of the dense stroma and high interstitial fluid pressure of solid tumors, the penetration of higher Mw compounds is unfavored and being small thus becomes an advantage. This review covers
Pablo Scodeller, Eliana K. Asciutto
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Targeting Toxins toward Tumors [PDF]
Molecules, 2021 Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states. In slowly developing cancer diseases only a minor part of the malignant cells will be in a proliferative state, and consequently these drugs will exert a ...
Henrik Franzyk +1 more
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BMC Cancer, 2023 Background Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells.
Shane O’Brien +8 more
doaj +1 more source
Targeting tumor resistance mechanisms [PDF]
Faculty Reviews, 2021 Cancer develops resistance to treatments through many mechanisms. Single-cell analyses reveal the intratumor heterogeneity and dynamic relationships between cancer cell subpopulations. These analyses also highlight that various mechanisms of resistance may coexist in a given tumor.
Gerard, Louise +2 more
openaire +2 more sources
Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy
Frontiers in Oncology, 2021 Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer.
Jianfeng Hua +8 more
doaj +1 more source
Signal Amplification-Based Biosensors and Application in RNA Tumor Markers
Sensors, 2023 Tumor markers are important substances for assessing cancer development. In recent years, RNA tumor markers have attracted significant attention, and studies have shown that their abnormal expression of post-transcriptional regulatory genes is associated
Haiping Li +7 more
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Study of Oncolytic Virus Preservation and Formulation
Pharmaceuticals, 2023 In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying ...
Lina Pan +6 more
doaj +1 more source
Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages
Journal of Translational Medicine, 2023 Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immunotherapy.
Zhen Shen +7 more
doaj +1 more source
Targeting neuropilin-1 interactions is a promising anti-tumor strategy
Chinese Medical Journal, 2021 . Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells
Shao-Dan Liu +4 more
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