Results 1 to 10 of about 9,826,714 (353)

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice. [PDF]

, 2015
UnlabelledPeritoneal disseminated cancer is highly treatment resistant. We here report the efficacy of intraperitoneal (i.p.) administration of tumor-targeting Salmonella typhimurium A1-R in a nude mouse model of disseminated human ovarian cancer.
Bouvet, Michael, Hiroshima, Yukihiko, Hoffman, Robert M, Matsubara, Hisahiro, Matsumoto, Yasunori, Miwa, Shinji, Toneri, Makoto, Tsuchiya, Hiroyuki, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya, Zhang, Yong, Zhao, Ming   +12 more
core   +28 more sources

Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment

Journal of Personalized Medicine, 2021
Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent in most of anticancer drugs is their lack of tumor selectivity.
M. Subhan, Satya Siva Kishan Yalamarty, N. Filipczak, F. Parveen, V. Torchilin   +4 more
semanticscholar   +1 more source

Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy/internal irradiation combination therapy

Journal of Nanobiotechnology, 2022
Exosomes are nanoscale monolayer membrane vesicles that are actively endogenously secreted by mammalian cells. Currently, multifunctional exosomes with tumor-targeted imaging and therapeutic potential have aroused widespread interest in cancer research ...
Congcong Wang, Ning Li, Yutian Li, Shasha Hou, Wenxin Zhang, Z. Meng, Shen Wang, Q. Jia, Jian Tan, Ren-fei Wang, Ruiguo Zhang   +10 more
semanticscholar   +1 more source

Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer

BMC Cancer, 2023
Background Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells.
Shane O’Brien, Michael Butticello, Christine Thompson, Boris Wilson, Anastasia Wyce, Vivek Mahajan, Ryan Kruger, Helai Mohammad, Andy Fedoriw   +8 more
doaj   +1 more source

Novel Tumor-Targeting Nanoparticles for Cancer Treatment—A Review

International Journal of Molecular Sciences, 2022
Being one of the leading causes of death and disability worldwide, cancer represents an ongoing interdisciplinary challenge for the scientific community.
Adelina-Gabriela Niculescu, A. Grumezescu   +1 more
semanticscholar   +1 more source

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Frontiers in Oncology, 2021
Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer.
Jianfeng Hua, Pan Wu, Lu Gan, Zhikun Zhang, Jian He, Liping Zhong, Yongxiang Zhao, Yong Huang, Yong Huang   +8 more
doaj   +1 more source

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Sensors, 2023
Tumor markers are important substances for assessing cancer development. In recent years, RNA tumor markers have attracted significant attention, and studies have shown that their abnormal expression of post-transcriptional regulatory genes is associated
Haiping Li, Zhikun Zhang, Lu Gan, Dianfa Fan, Xinjun Sun, Zhangbo Qian, Xiyu Liu, Yong Huang   +7 more
doaj   +1 more source

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids

Journal for ImmunoTherapy of Cancer, 2021
Background Tumor-specific cytotoxic T cells and T cell receptors are effective tools for cancer immunotherapy. Most efforts to identify them rely on known antigens or lymphocytes that have infiltrated into the tumor bed.
Qingda Meng, Shanshan Xie, G. K. Gray, M. Dezfulian, Omar Gandarilla, Weilin Li, Ling Huang, Dipikaa Akshinthala, E. Ferrer, Catherine Conahan, Sofia Perea, D. Pino, Joseph M Grossman, S. Elledge, M. Hidalgo, S. Muthuswamy   +15 more
semanticscholar   +1 more source

An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Fibroblast activation protein (FAP) has recently emerged as a tumor-associated antigen with abundant and selective expression in the majority of human solid malignancies.
J. Millul, G. Bassi, Jacqueline Mock, Abdullah Elsayed, C. Pellegrino, Aureliano Zana, Sheila Dakhel Plaza, Lisa Nadal, Andreas Gloger, Eleonore Schmidt, I. Biancofiore, Etienne J. Donckèle, Florent Samain, D. Neri, S. Cazzamalli   +14 more
semanticscholar   +1 more source

Study of Oncolytic Virus Preservation and Formulation

Pharmaceuticals, 2023
In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying ...
Lina Pan, Xiyu Liu, Dianfa Fan, Zhangbo Qian, Xinjun Sun, Pan Wu, Liping Zhong   +6 more
doaj   +1 more source