Results 231 to 240 of about 755,200 (268)

Tumor antigen targets and tumor immunotherapy

Frontiers in Bioscience, 2006
Tumor immunology and immunotherapy attempt to use the exquisite specificity and lytic capability of the immune system to treat malignant disease with a minimum of damage to normal tissue. Increasing knowledge of the identity of tumor antigens should point the way to effective therapeutic vaccines or more specific immunotherapeutic strategies.
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Targeting Tumor Lymphangiogenesis: An Update

Current Medicinal Chemistry, 2010
Various human tumors preferentially metastasize by lymphatic route and lymphovascular invasion predicts lymph node metastasis. In this review article, we will summarize recent literature data concerning lymphangiogenesis, focusing on tumor lymphangiogenesis.
RAICA M, RIBATTI, Domenico
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Branched Neurotensin for Tumor Targeting

2010
Introduction One of the major problems in classic chemotherapy is the non-specific toxicity of most anticancer agents against normal cells. The specific targeting of tumors has been the main challenge in research on cancer therapy and diagnosis.
FALCIANI C., FABRINI M., LELLI B., LOZZI L., PINI A., BRACCI L.   +5 more
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Targeting of the tumor microenvironment by curcumin

BioFactors, 2021
AbstractThe tumor microenvironment (TME) is made up of several cells and molecules that affect the survival of cancer cells. Indeed, certain (immunosuppressive) cells which promote tumors can promote the growth of tumors by stimulating the proliferation of cancer cells and promoting angiogenesis.
Xiao Fu, Yingni He, Mu Li, Zezhi Huang, Masoud Najafi   +4 more
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p62 as a therapeutic target for tumor

European Journal of Medicinal Chemistry, 2020
p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural
Mengmin, Tao, Tian, Liu, Qidong, You, Zhengyu, Jiang   +3 more
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Targeted Tumor Therapies at a Glance

Current Drug Targets, 2009
Conventional tumor therapy is usually based on surgery, radiation and chemotherapy. Treatment with chemotherapeutics is often impeded by dose-limiting toxicities. Therefore, medical scientists sought for tools to improve chemotherapy by directly coupling targeting molecules to cytotoxic substances.
H, Fuchs, C, Bachran
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Fibronectin as target for tumor therapy

International Journal of Cancer, 2005
During cancer progression, the extracellular matrix (ECM) of the tissue in which the tumor grows is extensively remodeled, both by degradation of preexisting ECM molecules and by the neosynthesis of ECM components, which in many cases are not present in the ECM of normal tissues. Fibronectin (FN), a class of high-molecular-weight adhesive glycoproteins,
Kaspar M, Zardi L, Neri D
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Tumor‐Targeted Catalytic Immunotherapy

Advanced Materials
Abstract Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting catalytic immunotherapy by modulating the immunosuppressive tumor microenvironment ...
En‐Li Yang, Wu‐Yin Wang, Ying‐Qi Liu, Hong Yi, Aiwen Lei, Zhi‐Jun Sun   +5 more
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Tumor Stroma as a Target in Cancer

Current Cancer Drug Targets, 2008
Solid tumors are composed of the malignant cell itself (most commonly a carcinoma) and supporting cells that comprise the stroma. Significant stromal components include the extracellular matrix, supporting fibroblasts, vessels comprised of endothelium, pericytes and in some cases vascular smooth muscle, lymphatics and usually a major leukocyte ...
F, Ahmed, J C, Steele, J M J, Herbert, N M, Steven, R, Bicknell   +4 more
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Advances in Tumor Targeted Liposomes

Current Molecular Medicine, 2018
Cancer remains a deadly disease for effective treatment. Although anomalous tumor microenvironment is now widely exploited for targeted chemotherapy, safe and efficacious drug delivery to tumor cells is not still warranted. Liposomes are promising biodegradable and biocompatible nanocarriers having potential amenability for surface and internal ...
A, Jain, , Jain
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