Aptamer Combined with Fluorescent Silica Nanoparticles for Detection of Hepatoma Cells
Nanoscale Research Letters, 2017 Purpose The purpose of this study is to develop a simple, effective method to label hepatoma cells with aptamers and then detect them using fluorescent silica nanoparticles (FSNPs).
Zixi Hu +12 more
doaj +1 more source
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. [PDF]
, 2017 SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane ...
Bufalieri, Francesca +18 more
core +2 more sources
Theranostics, 2020 Interest of tumor targeting through EPR effect is still controversial due to intrinsic low targeting efficacy and rare translation to human cancers. Moreover, due to different reasons, it has generally been described for relatively large nanoparticles ...
G. Bort +5 more
semanticscholar +1 more source
Targeting thapsigargin towards tumors [PDF]
Steroids, 2015 The skin irritating principle from Thapsia garganica was isolated, named thapsigargin and the structure elucidated. By inhibiting the sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) thapsigargin provokes apoptosis in almost all cells. By conjugating thapsigargin to peptides, which are only substrates for either prostate specific antigen (PSA) or ...
Christensen, Søren Brøgger +8 more
openaire +3 more sources
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
, 2017 The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert +3 more
core +2 more sources
Correction to: A Graphene Oxide-Based Fluorescent Aptasensor for the Turn-on Detection of CCRF-CEM
Nanoscale Research Letters, 2018 In the original publication of this article [1] the author Liping Zhong was omitted. In this correction article the author and the corresponding details are provided. The publisher apologizes to the readers and authors for the inconvenience.
Jie Tan +11 more
doaj +1 more source
The Tree Shrew as a Model for Cancer Research
Frontiers in Oncology, 2021 Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer.
Tao Lu +6 more
doaj +1 more source
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer. [PDF]
, 2017 Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress.
Angelastro, James M, Sears, Thomas K
core +2 more sources
Construction of Human Monocyte Derived Macrophages Armed with Oncolytic Viruses
Bio-Protocol, 2013 Macrophages are involved in many key physiological processes and complex responses such as inflammatory, immunological, infectious and neoplastic diseases.
Munitta Muthana +3 more
doaj +1 more source
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source