Results 91 to 100 of about 368,028 (305)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

Pharmaceutics, 2017
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment—due to the hostile tumor microenvironment—that create a significant challenge for effective therapeutic regimens.
Janel Kydd, Rahul Jadia, Praveena Velpurisiva, Aniket Gad, Shailee Paliwal, Prakash Rai   +5 more
doaj   +1 more source

Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry. [PDF]

, 2019
To evaluate the association between a vessel size index (VSIMRI) derived from dynamic susceptibility contrast (DSC) perfusion imaging using a custom spin-and-gradient echo echoplanar imaging (SAGE-EPI) sequence and quantitative estimates of vessel ...
Chakhoyan, Ararat, Cloughesy, Timothy F, Ellingson, Benjamin M, Everson, Richard G, Lai, Albert, Leu, Kevin, Liau, Linda M, Nathanson, David A, Nghiemphu, Phioanh L, Pope, Whitney B, Prins, Robert M, Salamon, Noriko, Yao, Jingwen, Yong, William   +13 more
core   +2 more sources

Circulating Endothelial Progenitors and Tumor Resistance to Vascular-Targeting Therapies

Cancer Discovery, 2012
Abstract Acute mobilization of circulating endothelial progenitors has been implicated in tumor resistance to vascular-disrupting agents. In the current issue of Cancer Discovery, Taylor and colleagues provide novel insight into the kinetics of endothelial progenitor mobilization by vascular-disrupting agents in both mouse tumor models ...
De Palma, M., Nucera, S.
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Tumor-Targeted nitric Oxide-Loaded nanoliposomes for modulating the tumor microenvironment and enhancing the efficacy of dacarbazine in melanoma

Materials & Design
Background: Malignant melanoma is a highly malignant tumor that results from the malignant transformation of melanocytes. It is mainly accompanied by changes in the immune microenvironment and severe intra-tumor vascular abnormalities, which ...
Yueling Yang, Jiaxuan Gan, Ziyao Xie, Xinyu Su, Yirong Wu, Lanqun Qin, Jiayu Wang, Mengke Zhao, Zhengyun Zou   +8 more
doaj   +1 more source

Acute Tumor Response to ZD6126 Assessed by Intrinsic Susceptibility Magnetic Resonance Imaging

Neoplasia: An International Journal for Oncology Research, 2005
The effective magnetic resonance imaging (MRI) transverse relaxation rate R2* was investigated as an early acute marker of the response of rat GH3 prolactinomas to the vascular-targeting agent, ZD6126.
Simon P. Robinson, Tammy L. Kalber, Franklyn A. Howe, Dominick J.O. McIntyre, John R. Griffiths, David C. Blakey, Lynsey Whittaker, Anderson J. Ryan, John C. Waterton   +8 more
doaj   +1 more source

Hypoxic Cell Waves around Necrotic Cores in Glioblastoma: A Biomathematical Model and its Therapeutic Implications

, 2012
Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hiperplasia.
Calvo, Gabriel F., Martínez-González, Alicia, Pérez-García, Víctor M., Romasanta, Luis A. Pérez   +3 more
core   +1 more source

PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor [PDF]

, 2019
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed.
Abramovich, Dalhia Nurit, Bocchicchio, Sebastian, Irusta, Griselda, May, Maria, Parborell, Maria Fernanda Agustina, Pazos Maidana, María Camila, Sequeira, Gonzalo Ricardo, Tesone, Marta   +7 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source