Results 261 to 270 of about 368,028 (305)
Some of the next articles are maybe not open access.
Targeting tumor vascularization: promising strategies for vascular normalization
Journal of Cancer Research and Clinical Oncology, 2021Tumor recurrence after the clinical cure of tumor often results from the presence of an abnormal microenvironment, including an aberrant vasculature. The tumor microenvironment is rich in pro-angiogenic factors but lacks pro-maturation factors. Pro-angiogenic conditions in the tumor microenvironment, such as hypoxia, are double-edged swords, promoting ...
Ruiqi Zheng +3 more
openaire +2 more sources
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2007
The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary
J, Ahlskog, G, Paganelli, D, Neri
openaire +3 more sources
The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary
J, Ahlskog, G, Paganelli, D, Neri
openaire +3 more sources
Drugs of the Future, 2006
Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
openaire +1 more source
Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
openaire +1 more source
Combination Vascular Targeted and Tumor Targeted Radioimmunotherapy
Cancer Biotherapy and Radiopharmaceuticals, 1999Rat MAb 201B, which binds to murine thrombomodulin, can deliver up to 50% of the injected dose of attached radioisotopes to the lung vascular endothelium. We have shown previously that intravenous injection of about 30 microCi of 213Bi-MAb 201B, which delivers about 15 Gy of alpha irradiation to the lung, is capable of eradicating small lung colonies ...
S J, Kennel +5 more
openaire +2 more sources
Tumor vascular targeting therapy with viral vectors
Blood, 2006AbstractTumor angiogenesis is crucial for the progression and metastasis of cancer. The vasculature of tumor tissue is different from normal vasculature. Therefore, tumor vascular targeting therapy could represent an effective therapeutic strategy with which to suppress both primary tumor growth and tumor metastasis.
Yanzheng, Liu, Albert, Deisseroth
openaire +2 more sources
Antibody-Based Vascular Tumor Targeting
2009The inhibition of angiogenesis represents a major step toward a more selective and better-tolerated therapy of cancer. An alternative way to take advantage of a tumor's absolute dependence on a functional neovasculature is illustrated by the strategy of "antibody-based vascular tumor targeting." This technology aims at the selective delivery of ...
Christoph, Schliemann, Dario, Neri
openaire +2 more sources
Tumor angiogenesis and vascular normalization: alternative therapeutic targets
Angiogenesis, 2017Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal vascular network characterized by disorganized, immature and permeable blood vessels, resulting in poorly perfused tumors.
Claire, Viallard, Bruno, Larrivée
openaire +2 more sources
Tumor Vascular Targeting with Tumor Necrosis Factor α and Chemotherapeutic Drugs
Annals of the New York Academy of Sciences, 2004Abstract: The poor selectivity of chemotherapeutic drugs for neoplastic cells may lead to dose‐limiting side effects that compromise clinical outcomes. Moreover, heterogeneous tumor perfusion and vascular permeability, and increased interstitial pressure, could represent critical barriers that limit the penetration of drugs into neoplastic cells ...
CORTI , ANGELO, Ponzoni M.
openaire +3 more sources