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Tumor Vascular Endothelium: Barrier or Target in Tumor Directed Drug Delivery and Immunotherapy
Pharmaceutical Research, 1997The therapy of solid tumors with conventional chemotherapeutics, drug delivery preparations and immunomodulatory agents directed against the tumor cells is corrupted by a major barrier presented by the tumor vasculature. Permeability of the tumor blood vessels for transport of small molecules and macromolecular drug-carrier conjugates is only ...
Molema, G, de Leij, Lou, Meijer, D.K F
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Vascular Integrins in Tumor Angiogenesis: Mediators and Therapeutic Targets
Endothelium, 2006The notion that tumor angiogenesis may have therapeutic implications in the control of tumor growth was introduced by Dr. Judah Folkman in 1971. The approval of Avastin in 2004 as the first antiangiogenic systemic drug to treat cancer patients came as a validation of this visionary concept and opened new perspectives to the treatment of cancer.
Gian Carlo, Alghisi, Curzio, Rüegg
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Photodynamic Tumor Vascular Targeting Enhances Cancer Chemotherapy
Frontiers in Optics, 2006Cancer drug therapy is limited by inadequate and heterogeneous tumor drug delivery due to the existence of vascular barrier. Photodynamic tumor vascular targeting is shown to disrupt tumor vascular barrier and enhance cancer chemotherapy.
Bin Chen +3 more
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Milestones in tumor vascularization and its therapeutic targeting
Nature CancerResearch into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising therapeutic target. The biological knowledge and therapeutic insights forthcoming have been remarkable,
Michele De Palma, Douglas Hanahan
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Vascular Integrins: Therapeutic and Imaging Targets of Tumor Angiogenesis
2009Cells, including endothelial cells, continuously sense their surrounding environment and rapidly adapt to changes in order to assure tissues and organs homeostasis. The extracellular matrix (ECM) provides a physical scaffold for cell positioning and represents an instructive interface allowing cells to communicate over short distances.
Curzio, Rüegg, Gian Carlo, Alghisi
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Potential role of vascular targeted therapy to combat against tumor
Expert Opinion on Drug Delivery, 2009Tumors, like other tissues, have a fundamental requirement for access to the nutrients, oxygen and waste removal functions of the circulatory system. Vascular targeted therapy exploits this basic need, along with molecular heterogeneity observed between normal and tumor blood vessels, to develop efficient and selective chemotherapies that essentially ...
Bei, Chen, Haifeng, Jin, Kaichun, Wu
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Vascular endothelial growth factor and vascular targeting of solid tumors.
Anticancer research, 2002Vascular targeting agents, which selectively destroy tumor blood vessels, are attractive agents for the treatment of solid tumors. They differ from anti-angiogenic agents in that they target the mature, blood-conducting vessels of the tumors. They are better suited for larger tumors where angiogenesis can occur less frequently.
R A, Brekken, P E, Thorpe
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Targeting the tumor vascular compartment to improve conventional cancer therapy
Trends in Pharmacological Sciences, 2004The fact that a single blood vessel can support the life of thousands of tumor cells has been known for a long time. However, therapeutic strategies that aim to impair vascular development in tumors are only slowly emerging in the clinics. Nevertheless, the accumulation of data from many successful preclinical studies of the effects of a variety of ...
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CAF-mediated tumor vascularization: From mechanistic insights to targeted therapies
Cellular SignallingCancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment (TME) and play a crucial role in tumor progression. The biological properties of tumors, such as drug resistance, vascularization, immunosuppression, and metastasis are closely associated with CAFs.
Zhi, Zhang, Qing, Zhang, Yang, Wang
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VASCULARIZING THE TUMOR: TRP CHANNELS AS MOLECULAR TARGETS.
2012Tumor vascularization is a critical process that determines tumor growth and metastasis. In the last decade new experimental evidence obtained from in vitro and in vivo studies have challenged the classical angiogenesis model forcing us to consider new scenarios for tumor neovascularization.
FIORIO PLA, ALESSANDRA +3 more
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