Results 171 to 180 of about 1,359,527 (294)

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature. [PDF]

Cell
Subudhi S, Lee S, Jain RK.
europepmc   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Feasibility of multiomics tumor profiling for guiding treatment of melanoma

There is limited evidence supporting the feasibility of using omics and functional technologies to inform treatment decisions. Here we present results from a cohort of 116 melanoma patients in the prospective, multicentric observational Tumor Profiler ...
Frei, Anja, Irmisch, Anja, Baciu-Drăgan, Monica-Andreea, Ring, Alexander, Tusup, Marina, Schuerch, Manuel, Beisel, Christian, Lehmann, Kjong-Van, Gosztonyi, Benedict, Rätsch, Gunnar, Chicherova, Natalia, Bertolini, Anne, Heinzelmann, Viola, Theocharides, Alexandre, Rahimzadeh, Parisa, Bonilla, Ximena, Chevrier, Stéphane, Pelkmans, Lucas, Maass, Gerd, Lischetti, Ulrike, Dummer, Reinhard, Sivapatham, Sujana, Wicki, Andreas, Boos, Laura Amanda, Mena, Julien, Gut, Gabriele, Wollscheid, Bernd, Nowak, Marta, Toussaint, Nora Christina, Milani, Emanuela S., del Castillo, Jacobo Sarabia, Beerenwinkel, Niko, Prummer, Michael, Snijder, Berend, Goetze, Sandra, Moch, Holger, Ferreira, Pedro, Sobottka, Bettina, Casanova, Ruben, Jacobs, Alice K., Koelzer, Viktor H., Kuipers, Jack, Bacac, Marina, Miglino, Nicola, Jacob, Francis, Aebersold, Ruedi, Weller, Michael, Wegmann, Rebekka, Manz, Markus G., Mehra, Tarun, Esposito, Cinzia, Bodenmiller, Bernd, Singer, Franziska, Levesque, Mitchell P., Yu, Shuqing   +54 more
core   +1 more source

ROS impairs tumor vasculature normalization through an endocytosis effect of caveolae on extracellular SPARC. [PDF]

Cancer Cell Int, 2023
Zhao Y, Yu J, Huang A, Yang Q, Li G, Yang Y, Chen Y.   +6 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Deficiency of GLUT1 in macrophages reprograms tumor-associated macrophages to normalize tumor vasculature and retards the progression of tumors. [PDF]

Int J Biol Sci
Fang Y, Zou W, Ning L, Li T, Huang Y, Song X, Gao M, Jia R, Zhu M, Qiu W, Liu K, Wang A, Li J, Lu Y, Zhao Y.   +14 more
europepmc   +1 more source

Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress. [PDF]

J Clin Invest, 2023
Yang ZY, Yan XC, Zhang JY, Liang L, Gao CC, Zhang PR, Liu Y, Sun JX, Ruan B, Duan JL, Wang RN, Feng XX, Che B, Xiao T, Han H.   +14 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

CXC Chemokine-Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response. [PDF]

Adv Sci (Weinh)
Chen H, Huang Y, Wu J, Yi Z, Li Y, Yang Z, Zhang F, Li C.   +7 more
europepmc   +1 more source