Results 1 to 10 of about 527,270 (344)
Autophagy and tumorigenesis [PDF]
The FEBS Journal, 2021 Autophagy is a catabolic process that captures cellular waste and degrades them in the lysosome. The main functions of autophagy are quality control of cytosolic proteins and organelles, and intracellular recycling of nutrients in order to maintain cellular homeostasis.
Michael Rangel +4 more
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Frontiers in Pharmacology, 2023 Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered.
Ji-Chao Zhou +20 more
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TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target
Acta Pharmaceutica Sinica B, 2021 Pulmonary fibrosis (PF) is a chronic, progressive, fatal interstitial lung disease with limited available therapeutic strategies. We recently reported that the protein kinase glycogen synthase kinase-3β (GSK-3β) interacts with and inactivates the ...
Shanshan Liu +12 more
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Control of cell death/survival balance by the MET dependence receptor
eLife, 2020 Control of cell death/survival balance is an important feature to maintain tissue homeostasis. Dependence receptors are able to induce either survival or cell death in presence or absence of their ligand, respectively. However, their precise mechanism of
Leslie Duplaquet +13 more
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Crosstalk between ferroptosis and stress—Implications in cancer therapeutic responses
Cancer Innovation, 2022 Ferroptosis is a newly discovered form of cell death that is characterized by the accumulation of iron‐dependent lipid peroxidation. Research on ferroptosis has seen exponential growth over the past few years.
Cheng Zhang +6 more
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Bone Metastasis: Current State of Play
Translational Oncology, 2020 Bone metastasis (BM) in cancer remains a critical issue because of its associated clinical and biological complications. Moreover, BM can alter the quality of life and survival rate of cancer patients.
Anthony Turpin +2 more
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Protein acylation: mechanisms, biological functions and therapeutic targets
Signal Transduction and Targeted Therapy, 2022 Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases.
Shuang Shang, Jing Liu, Fang Hua
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Hypoxia in Solid Tumors: How Low Oxygenation Impacts the “Six Rs” of Radiotherapy
Frontiers in Endocrinology, 2021 Radiotherapy is an important component of cancer treatment, with approximately 50% of all cancer patients receiving radiation therapy during their course of illness.
Andria Rakotomalala +11 more
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Stem Cell Reports, 2017 The lymphoid-myeloid transdifferentiation potentials of members of the C/EBP family (C/EBPα, β, δ, and ε) were compared in v-Abl-immortalized primary B cells. Conversion of B cells to macrophages was readily induced by the ectopic expression of any C/EBP,
Branko Cirovic +7 more
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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
Cell Reports, 2021 Summary: Cell death provides host defense and maintains homeostasis. Zα-containing molecules are essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell death, PANoptosis, whereas adenosine deaminase acting on RNA 1 ...
Rajendra Karki +12 more
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