Results 21 to 30 of about 527,270 (344)
The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse
Scientific Reports, 2018 The transcription factor C/EBPβ regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPβ protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start ...
Valérie Bégay +4 more
doaj +1 more source
Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis
Frontiers in Cardiovascular Medicine, 2022 Recently, the extracellular matrix protein agrin has been reported to promote tumor angiogenesis that supports tumorigenesis and metastasis; however, there is a lack of in vivo genetic evidence to prove whether agrin derived from the tumors or ...
Peng Ye +10 more
doaj +1 more source
Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]
, 2018 Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core +2 more sources
Optogenetic investigation of BMP target gene expression diversity
eLife, 2020 Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis.
Katherine W Rogers +3 more
doaj +1 more source
Frontiers in Oncology, 2022 Lung cancer is the leading cause of cancer-related death worldwide. Cancer immunotherapy has shown great success in treating advanced-stage lung cancer but has yet been used to treat early-stage lung cancer, mostly due to lack of understanding of the ...
Wei-Wei Chen +7 more
doaj +1 more source
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Nature Communications, 2016 It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence
Joe Nassour +13 more
doaj +1 more source
Cells, 2019 Background: The role of regulatory T cells (Tregs) is now well established in the progression of hepatocellular carcinoma (HCC) linked to Hepatitis C virus (HCV) infection. However, nothing is known about the potential interplay between Tregs and HCV. In
Laurissa Ouaguia +8 more
doaj +1 more source
Toward Cultural Oncology: The Evolutionary Information Dynamics of Cancer [PDF]
, 2003 'Racial' disparities among cancers, particularly of the breast and prostate, are something of a mystery. For the US, in the face of slavery and its sequelae, centuries of interbreeding have greatly leavened genetic differences between 'Blacks' and ...
Wallace, Deborah +2 more
core +2 more sources
Autophagy and Tumorigenesis [PDF]
Seminars in Immunopathology, 2010 Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors.
Roy, Srirupa, Debnath, Jayanta
openaire +4 more sources