Results 31 to 40 of about 504,448 (294)
Autophagy and Tumorigenesis [PDF]
Seminars in Immunopathology, 2010 Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors.
Roy, Srirupa, Debnath, Jayanta
openaire +4 more sources
The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo
International Journal of Cell Biology, 2011 The mammary gland is a unique organ that continually undergoes postnatal developmental changes. In mice, the mammary gland is formed via signals from terminal end buds, which direct ductal growth and elongation.
Karen M. Bussard, Gilbert H. Smith
doaj +1 more source
DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
Neoplasia: An International Journal for Oncology Research, 2017 DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4.
Nanda Kumar Sasi +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Hepatocellular carcinoma (HCC) is a common primary liver cancer with ∼750,000 annual incidence rates globally. PGE2, usually known as a pro-inflammatory cytokine, is over-expressed in various human malignancies including HCC.
Chao Chen +4 more
doaj +1 more source
APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. [PDF]
, 2020 Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin,
Bashir, Babar +7 more
core +1 more source
RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]
, 2016 Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana +17 more
core +1 more source
Radiation-induced Tumorigenesis [PDF]
BMB Reports, 2003 During the past 2 decades, radiation tumorigenesis researchers have focused on cellular and molecular mechanisms. We reviewed some of these research fields, since they may specifically relate to the induction of cancer by ionizing radiation. First, radiation-mediated mutation was discussed. Then the initiating event in radiation carcinogenesis, as well
In-Gyu, Kim, Yun-Sil Lee, Lee
openaire +2 more sources
Evaluation of LRIG1 Expression in Larynx Pathologies
The Turkish Journal of Ear Nose and Throat, 2022 Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found.
Yavuz Gündoğdu +6 more
doaj +1 more source
DACH1 suppresses breast cancer as a negative regulator of CD44. [PDF]
, 2017 Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack ...
Kuang, Dong +6 more
core +2 more sources
Acetyl-CoA Carboxylases and Diseases
Frontiers in Oncology, 2022 Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs.
Yu Wang +7 more
doaj +1 more source