Results 41 to 50 of about 504,448 (294)

JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]

, 2013
Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Adams, Ahmed, Anbalagan, Annunziata, Antonyak, Bain, Barbarulo, Barr, Behrens, Bennett, Bharti, Bogoyevitch, Bogoyevitch, Borsello, Bost, Carboni, Cazanave, Cellurale, Cellurale, Cellurale, Chang, Chang, Chauhan, Chen, Chen, Chen, Chen-Deutsch, Cho, Choi, Chromik, Cilloni, Cripe, Cui, Cui, Das, Davis, Deininger, Dérijard, Eferl, Estey, Farazi, Ferrandi, Finegan, Fuchs, Gaillard, Gao, Gao, Gilmore, Goenka, Graff, Gururajan, Hagiwara, He, Heo, Hess, Hideshima, Hideshima, Hideshima, Hirosumi, Ho, Huang, Hui, Hunot, Jaeschke, Jagtap, Jemal, Johnson, Kamenecka, Kaneto, Kaoud, Ke, Keats, Kersting, Kuan, Kuperwasser, Li, Llovet, Lloyd, LoGrasso, Luedde, Maclean, Maeda, Mamay, Manning, Manning, Min, Mucha, Murati, Nagata, Nateri, Ngoei, Ngoei, Nitta, Oleinik, Owens, Papa, Papa, Plantevin Krenitsky, Qiu, Raitano, Reinecke, Ricard, Rodrigues, Ronaldson, Roy, Sabapathy, Sakurai, Schramek, Seki, She, Siddiqui, Smeal, Srivastava, Stebbins, Su, Su, Szczepankiewicz, Takahashi, Tong, Tournier, Tsuiki, Waetzig, Wagner, Wang, Wang, Webster, Whitmarsh, Whitmarsh, Yamamoto, Yan, Yang, Yao, Yoon, Yoshida, Zhang, Zhang, Zhang, Zhang   +137 more
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BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

EMBO Molecular Medicine, 2017
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly ...
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas   +20 more
doaj   +1 more source

ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. [PDF]

, 2017
There is a geographic inequality in the incidence of colorectal cancer, lowest in developing countries, and greatest in developed countries.
Li, Peng, Lin, Jieru E., Snook, Adam E., Waldman, Scott A.   +3 more
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Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

, 2019
Erratum for: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Bardeesy, N., Boukhali, M., Chen, T., Dyson, N., Gu, H., Haas, W., Hammerman, P., Hayes, D., Hayward, M., Karnik, R., Kottakis, F., Li, Y., Liesa, M., Meissner, A., Nagle, J., Nicolay, B., Roumane, A., Shirihai, O., Wong, K.   +18 more
core   +1 more source

Long non-coding RNA SOX2OT: Expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis [PDF]

, 2015
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region.
Jazi, M.S., Mowla, S.J., Samaei, N.M., Shahryari, A.   +3 more
core   +1 more source

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

EMBO Molecular Medicine, 2019
Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression.
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas   +23 more
doaj   +1 more source

Oncogenic microRNAs characterization in clear cell renal cell carcinoma [PDF]

, 2015
A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of
BELLISSIMO, TERESA, CARBONE, Antonio, DELLA ROCCA, Carlo, DI CARLO, ANGELINA, FAZI, Francesco, PALLESCHI, GIOVANNI, PASTORE, ANTONIO LUIGI, PETROZZA, Vincenzo, PORTA, NATALE   +8 more
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The roles of the tumor suppressor parafibromin in cancer

Frontiers in Cell and Developmental Biology, 2022
In this review, we discuss parafibromin protein, which is encoded by CDC73. A mutation in this gene causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disease.
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
doaj   +1 more source

s-SHIP Promoter Expression Identifies Mouse Mammary Cancer Stem Cells

Stem Cell Reports, 2019
Summary: During normal mammary gland development, s-SHIP promoter expression marks a distinct type of mammary stem cells, at two different stages, puberty and early mid-pregnancy. To determine whether s-SHIP is a marker of mammary cancer stem cells (CSCs)
Lu Tian, Marie-José Truong, Chann Lagadec, Eric Adriaenssens, Emmanuel Bouchaert, Hélène Bauderlique-Le Roy, Martin Figeac, Xuefen Le Bourhis, Roland P. Bourette   +8 more
doaj   +1 more source

RAB42 Promotes Glioma Pathogenesis via the VEGF Signaling Pathway

Frontiers in Oncology, 2021
Angiogenesis plays an important role in tumor initiation and progression of glioma. Seeking for biomarkers associated with angiogenesis is important in enhancing our understanding of glioma biologically and identifying its new drug targets.
Baoling Liu, Quanping Su, Bolian Xiao, Guodong Zheng, Lizhong Zhang, Jiawei Yin, Lijuan Wang, Lijuan Wang, Fengyuan Che, Fengyuan Che, Xueyuan Heng   +10 more
doaj   +1 more source