Results 1 to 10 of about 155,806 (387)

Ectoine Globally Hypomethylates DNA in Skin Cells and Suppresses Cancer Proliferation

open access: yesMarine Drugs, 2023
Epigenetic modifications, mainly aberrant DNA methylation, have been shown to silence the expression of genes involved in epigenetic diseases, including cancer suppression genes.
Majjid A. Qaria   +7 more
doaj   +1 more source

YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A-Mediated Up-Regulation of RANBP2

open access: yesFrontiers in Oncology, 2021
N6-methyladenosine (m6A) is the most common post-transcriptional modification of RNA in eukaryotes, which has been demonstrated to play important roles in various cancers. YTHDF1 acts as a crucial m6A “reader” and regulates the fate of m6A modified mRNA.
Haocheng Wang   +8 more
doaj   +1 more source

Downregulation of ZNF280A inhibits proliferation and tumorigenicity of colorectal cancer cells by promoting the ubiquitination and degradation of RPS14

open access: yesFrontiers in Oncology, 2022
Colorectal cancer (CRC), one of the cancers with highest mortality, involves complicated molecular mechanisms leading to the onset of malignant phenotypes.
Binle Tian   +5 more
doaj   +1 more source

The expression level of chicken telomerase reverse transcriptase in tumors induced by ALV-J is positively correlated with methylation and mutation of its promoter region

open access: yesVeterinary Research, 2022
Avian leukosis virus subgroup J (ALV-J) can cause neoplastic diseases in poultry and is still widely prevalent in China. Chicken telomerase reverse transcriptase (chTERT) is the core component of telomerase, which is closely related to the occurrence and
Yong Xiang   +4 more
doaj   +1 more source

Anti-HERV-K Drugs and Vaccines, Possible Therapies against Tumors

open access: yesVaccines, 2023
The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer, lymphoma, and ovary and prostate cancers.
Sepideh Hosseiniporgham   +1 more
doaj   +1 more source

circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma

open access: yesOpen Medicine, 2023
Circular RNAs have been reported to be widely involved in cancer cell tumorigenesis and drug resistance; here, the aim of this study was to investigate whether circRNA Integrin Subunit Alpha 7 (ITGA7) (circ_ITGA7) was associated with the tumor growth and
Li Wei   +4 more
doaj   +1 more source

BCAT1 Activates PI3K/AKT/mTOR Pathway and Contributes to the Angiogenesis and Tumorigenicity of Gastric Cancer

open access: yesFrontiers in Cell and Developmental Biology, 2021
BackgroundFocusing on antiangiogenesis may provide promising choices for treatment of gastric cancer (GC). This study aimed to investigate the mechanistic role of BCAT1 in the pathogenesis of GC, particularly in angiogenesis.MethodsBioinformatics and ...
Xiong Shu   +8 more
doaj   +1 more source

High Expression of Citron Kinase Contributes to the Development of Esophageal Squamous Cell Carcinoma

open access: yesFrontiers in Genetics, 2021
ObjectiveThis study aimed to investigate the role and potential regulatory mechanism of citron kinase (CIT) in esophageal squamous cell carcinoma (ESCC).MethodsCitron kinase (CIT) expression in ESCC tissues was analyzed based on the microarray dataset ...
Wenfeng Lu   +6 more
doaj   +1 more source

An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1

open access: yesFrontiers in Oncology, 2023
Interferon-beta (IFN-β), an extracellular cytokine that initiates signaling pathways for gene regulation, has been demonstrated to function as a tumor suppressor protein through lentiviral gene transduction.
Albert Qin
doaj   +1 more source

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