Results 121 to 130 of about 5,827 (204)

The new Bruton’s tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres

Translational Oncology
Glioblastoma (GBM), the most prevalent primary brain tumor, remains incurable due to the presence of cancer stem cells (CSCs), which can be isolated as tumorspheres (TSs) that exhibit classical characteristics of CSCs, including stemness and invasiveness.
Euna Jo, Eun Lee, Yoojung Oh, Dongkyu Lee, Byungho Lee, Kibyeong Kim, Ran Joo Choi, Jiyun Hong, Yuesong Jeon, Hyewon Cho, Yong-Sung Choi, Sangwoo Kim, So Young Won, Seonah Choi, Tae Hoon Roh, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Raok Jeon, Seok-Gu Kang   +19 more
doaj   +1 more source

Induction of tumor initiation is dependent on CD44s in c-Met hepatocellular carcinoma [PDF]

, 2015

core   +1 more source

Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition

Journal of Translational Medicine
Background Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types of solid cancers.
Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirström, Konstantinos S. Papadakos, Anna M. Blom   +6 more
doaj   +1 more source

Focused ultrasound-mediated temozolomide delivery into intact blood–brain barrier tissue improves survival in patient-derived xenograft model of glioblastoma

Fluids and Barriers of the CNS
Background Glioblastoma (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by rapid proliferation and invasive infiltration into normal brain tissue. Despite maximal resection and temozolomide (TMZ) chemotherapy, over
Jaewoo Shin, Jin-Kyoung Shim, Chanho Kong, Younghee Seo, Sangheon Han, Seok-Gu Kang, Won Seok Chang   +6 more
doaj   +1 more source

Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma [PDF]

, 2016
Allonca Campa, Eva, Astudillo González, María Aurora, Martínez Cruzado, Lucía, Núñez González, Luz Elena, Oro Carbajosa, Patricia, Rodríguez García, Aida, Rodríguez González, René, Santos Duque, Laura, Suárez Nieto, Carlos, Tornin Cavielles, Juan   +9 more
core   +1 more source

Deciphering tumorsphere biology in ovarian cancer

[eng] Epithelial ovarian cancer (EOC) is the fifth-leading cause of cancer death among women and the most lethal gynecological malignancy. High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and aggressive subtype, accounting for 70% of ovarian cancer deaths. Survival rates are low due to late-stage diagnosis and ineffective therapies for
openaire   +2 more sources

Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy [PDF]

, 2008
Christine M Fillmore, Charlotte Kuperwasser, H Dvoark, M Al-Hajj, AT Collins, CA O'Brien, L Ricci-Vitiani, C Li, MF Clarke, RM Neve, M Lacroix, II Wistuba, T Sørlie, T Sørlie, G Jönsson, E Charafe-Jauffret, C Kuperwasser, P Gupta, C Sheridan, B Elenbaas, CM Perou, LJ van't Veer, M Shipitsin, R Pradal, D Ponti, SK Singh, D Bonnet, TC Somervaille, G Dontu, G Dontu, JR Bickenbach, GH Smith, RT Costello, G Liu, BK Abraham, AJ Minn, AJ Minn, F Li   +37 more
core   +1 more source

The Oncogenic Role of Serum Marker GDF15 in Promoting Colorectal Tumorigenesis via EMT and Stemness. [PDF]

Stem Cells Int
Xu H, Zhang Q, Li Q, Gu F, Wang D, Tian Y, Khatra H.   +6 more
europepmc   +1 more source

Phytochemical profiling and anticancer activity of the n-butanol fraction from Ardisia villosa extract: Inhibition of gastric cancer cell proliferation via cell cycle arrest and senescence induction. [PDF]

PLoS One
Hua NM, Pham VK, Le TTH, Pham SH, Hoang V, Trinh TH, Can DQH, Hoang VH, Nguyen PH.   +8 more
europepmc   +1 more source

PRMT5 upregulates KCNMB4 expression via histone methylation to promote paclitaxel resistance in advanced nasopharyngeal carcinoma. [PDF]

Cell Death Dis
Liu L, Liu S, Wang Y, Wang P, Zhong G, Hong JH, Xiao R, Guo Y, Zhu F, Hao J, Chen J, Mai HQ, Tan J.   +12 more
europepmc   +1 more source