Results 111 to 120 of about 5,827 (204)
Stem Cell Research & Therapy, 2017 Background Ring finger protein 43 (RNF43) is a member of the transmembrane E3 ubiquitin ligase family that was originally found in stem cells and plays important roles in tumor formation and progression. Our previous study indicated that RNF43 might be a
Yunhe Gao +10 more
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Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy [PDF]
, 2016 NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in some important cellular processes. Numb is a protein involved in cell development, in cell adhesion and migration, in asymmetric cell
Carnero Moya, Amancio +4 more
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Neuro-OncologyAbstract Background Glioblastoma (GBM), a primary malignant brain tumor, has a poor prognosis, even with standard treatments such as radiotherapy and chemotherapy. In this study, we explored the anticancer effects of the synergistic combination of perphenazine (PER), a dopamine receptor D2/3 (DRD2/3 ...
Jun Pyo Hong +15 more
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BiologyChemoresistance remains a major challenge in the treatment of breast and colorectal cancer. For this reason, finding reliable predictive biomarkers of response to chemotherapy has become a significant research focus in recent years.
Toni Martinez-Bernabe +10 more
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Characterization of tumorspheres generated from nasopharyngeal carcinoma cell line, TW06 and chemoresistance to docetaxel and oxaliplatin [PDF]
, 2015 In this study, tumorspheres were generated from TW06 nasopharyngeal carcinoma cell line and examined their expression of putative cancer stem-like cell surface markers and drug sensitivity.
Goh, Iris Wen Li +2 more
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Histology and histopathology, 2016 Nestin+cells from spheroid aggregates display typical histopathological features compatible with cell stemness. Nestin and CD133+cells found in glioblastomas, distributed frequently around aberrant vessels, are considered as potential cancer stem cells.
García Blanco, Alvaro +4 more
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Tumorsphere Passage for Breast Cancer Stem Cells [PDF]
Protocol Exchange, 2013 Pranela Rameshwar +2 more
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Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors Are of Malignant Origin
PLoS ONE, 2013 Verification that cell lines used for cancer research are derived from malignant cells in primary tumors is imperative to avoid invalidation of study results. Retinoblastoma is a childhood ocular tumor that develops from loss of functional retinoblastoma protein (pRb) as a result of genetic or epigenetic changes that affect both alleles of the RB1 gene.
Wesley S Bond +5 more
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Translational OncologyDespite available treatment approaches, including surgical resection along with chemotherapy and radiotherapy, glioblastoma (GBM), the most prevalent primary brain tumor, remains associated with a grim prognosis. Although radiotherapy is central to GBM treatment, its combination with bioenergetics regulators has not been validated in clinical practice.
Seo Jin Kim +8 more
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3D tumorsphere array-based invasion assay platform
Frontiers in Bioengineering and Biotechnology, 2016 Cha Junghwa, Kang Seok-Gu, Kim Pilnam
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