Results 91 to 100 of about 5,827 (204)

Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size [PDF]

, 2014
Background: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict due to the use of multiple applicators with complex spatial configuration.
Bellemann, Nadine, Fritz, Stefan, Gnutzmann, Daniel, Kauczor, Hans U., Knapp, Jürgen, Pereira, Philippe L., Radeleff, Boris A., Schmitz, Anne, Sommer, Christof M., Stampfl, Ulrike, Vollherbst, Dominik, Wachter, Miguel F., Werner, Jens, Wolf, Maya B, Zelzer, Sascha   +14 more
core   +1 more source

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

Advanced Science, Volume 13, Issue 20, 9 April 2026.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang, Yangfan Ye, Wei Gu, Xinyue Wang, Nuo Chen, Qixin He, Lei Xu, Pengzhan Zhao, Guoqiang Fu, Guangyao Yuan, Wenqian Shi, Honglu Chao, Yiming Tu, Jing Ji   +13 more
wiley   +1 more source

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response [PDF]

Neuro-Oncology, 2017
Advances from glioma stemlike cell (GSC) research, though increasing our knowledge of glioblastoma (GBM) biology, do not influence clinical decisions yet. We explored the translational power of GSC-enriched cultures from patient-derived tumorspheres (TS) in predicting treatment response.The relationship between TS growth and clinical outcome was ...
D'Alessandris QG, Biffoni M, Martini M, Runci D, Buccarelli M, Cenci T, Signore M, Stancato L, Olivi A, De Maria Marchiano R, Larocca LM, Ricci-Vitiani L, Pallini R.   +12 more
openaire   +6 more sources

Agarose Coated Culture Plate in Tumorsphere Culture of Cervical Cancer Cell Line HeLa: an Alternative to Non Adhesive Culture Plate [PDF]

, 2016
Cervical cancer recurs in 90% cases and linked to cancer stem cells that able to self-renew and responsible for recurrence, metastasis, and mortality of cancer.
Indra, M. R. (Muhammad), Juniartha, P. (Putu), Lyrawati, D. (Diana), Nurseta, T. (Tatit), Sujuti, H. (Hidayat)   +4 more
core   +1 more source

Cellular Characterization Using Microwave‐Assisted Immunocytochemistry, A Time‐Efficient Alternative to Traditional Immunocytochemistry

Current Protocols, Volume 6, Issue 4, April 2026.
Abstract Immunocytochemistry (ICC) and immunohistochemistry (IHC) are related but separate techniques used for cell and tissue characterization. ICC involves immunolabeling of cells, and IHC immunolabeling of tissues; thus, the main difference is sample thickness. However, the distinction between ICC and IHC is not always clear and can be confusing. We
Aidyn M. Medina‐López, Irma I. Torres‐Vázquez, Noraida Martínez‐Rivera, Eduardo Rosa‐Molinar   +3 more
wiley   +1 more source

Phenotypic and Expressional Heterogeneity in the Invasive Glioma Cells

Translational Oncology, 2019
BACKGROUND: Tumor cell invasion is a hallmark of glioblastoma (GBM) and a major contributing factor for treatment failure, tumor recurrence, and the poor prognosis of GBM. Despite this, our understanding of the molecular machinery that drives invasion is
Artem Fayzullin, Cecilie J. Sandberg, Matthew Spreadbury, Birthe Mikkelsen Saberniak, Zanina Grieg, Erlend Skaga, Iver A. Langmoen, Einar O. Vik-Mo   +7 more
doaj   +1 more source

Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells

Pharmaceutics, 2020
Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival.
Sara Montero, Joaquin Seras-Franzoso, Fernanda Andrade, Francesc Martinez-Trucharte, Mireia Vilar-Hernández, Manuel Quesada, Helena Xandri, Diego Arango, Ibane Abasolo, Diana Rafael, Simo Schwartz   +10 more
doaj   +1 more source

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages [PDF]

, 2018
The cell-biological program termed the epithelial-mesenchymal transition (EMT) confers on cancer cells mesenchymal traits and an ability to enter the cancer stem cell (CSC) state.
Bhargava, Rohit, Carr, Steven A., Clauser, Karl R., Donnenberg, Vera S., Eaton, Elinor Ng, Fröse, Julia, Lu, Haihui, Reinhardt, Ferenc, Tam, Wai Leong, Weinberg, Robert A, Ye, Xin   +10 more
core   +1 more source

Significance of CD133 positive cells in four novel HPV-16 positive cervical cancer-derived cell lines and biopsies of invasive cervical cancer

BMC Cancer, 2018
Background Cervical cancer is a major cause of cancer-related mortality in women in the developing world. Cancer Stem cells (CSC) have been implicated in treatment resistance and metastases development; hence understanding their significance is important.
Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal, Radhika Srinivasan   +8 more
doaj   +1 more source

Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma [PDF]

, 2017
Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood.
Acharya, Achuthan, Beck, Boumahdi, Cai, Chang, Chen, Chou, Condello, Diehn, Ding, Ding, Déliot, Gerlach, Holohan, Houghton, Huang, Hussenet, Ishimoto, Lam, Langmead, Levy, Li, Liu, Liu, Liu, Lu, Mizuno, Okumura, Pattabiraman, Prevarskaya, Qin, Raha, Roderick, Sanjana, Shi, Singh, Singh, Sun, Tomita, Ucar, Valent, Visvader, Werneck, Yang, Zhang, Zhang, Zhang, Zhao   +48 more
core   +2 more sources