Results 71 to 80 of about 5,827 (204)
International Journal of Cancer, EarlyView.Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki +12 more
wiley +1 more source
Molecular Carcinogenesis, EarlyView.ABSTRACT Excessive activation of the estrogen receptor (ER) drives proliferation, progression, and the formation of breast cancer stem cells (CSCs) in ER‐positive breast cancer. Estrogenic endocrine disrupting compounds (EDCs) found in plastics, water, and food are also able to bind to the ER.
Cassandra Winz +9 more
wiley +1 more source
A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1
Scientific Reports, 2022 Abstract Forkhead Box M1 (FOXM1) is known to regulate cell proliferation, apoptosis and tumorigenesis. The lignan, (−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol (DFS), from Alnus japonica has shown anti-cancer effects against colon cancer cells by suppressing FOXM1.
Jin-Kyoung Shim +15 more
openaire +4 more sources
High-Throughput Method for Automated Colony and Cell Counting by Digital Image Analysis Based on Edge Detection [PDF]
, 2016 Counting cells and colonies is an integral part of high-throughput screens and quantitative cellular assays. Due to its subjective and time-intensive nature, manual counting has hindered the adoption of cellular assays such as tumor spheroid formation in
Choudhry, Priya
core +4 more sources
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, EarlyView.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states [PDF]
, 2016 Z-cad sensor loses GFP expression early and gains RFP expression later upon miR-200c induction. All collected time points for time-lapse microscopy (from Fig. 1c) of identical grids within cell culture plate are shown for each treatment group.
Ellis, M. J +9 more
core +7 more sources
NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation
Advanced Science, Volume 13, Issue 26, 8 May 2026.NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi +14 more
wiley +1 more source
Simultaneous targeting of Eph receptors in glioblastoma [PDF]
, 2016 Eph tyrosine kinase receptors are frequently overexpressed and functional in many cancers, and they are attractive candidates for targeted therapy. Here, we analyzed the expression of Eph receptor A3, one of the most up-regulated factors in glioblastoma ...
Debinski, W +4 more
core +2 more sources
Food Frontiers, Volume 7, Issue 3, May 2026.Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), suppresses triple‐negative breast cancer growth and stemness by inducing mitochondrial‐mediated apoptosis and inhibiting the Wnt/β‐catenin pathway, highlighting its potential as a natural compound for the prevention and treatment TNBC.
Danhong Zheng +4 more
wiley +1 more source
Cell Communication and Signaling, 2019 Background Expression of CD44 receptor is associated with the onset of several tumors. The intracellular domain of CD44 (CD44-ICD) has been implicated as a co-transcription factor for RUNX2 in the regulation of expression of MMP-9 in breast carcinoma ...
Linda T. Senbanjo +3 more
doaj +1 more source