Results 51 to 60 of about 5,827 (204)

Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling

Biomedicines, 2023
Three-dimensional tumorsphere cultures recapitulate the expression of several cancer stem cell (CSC) biomarkers and represent an effective in vitro platform to screen the anti-CSC properties of drugs. Whereas ovarian carcinoma is among the leading causes
Sahily Rodriguez Torres, Loraine Gresseau, Meriem Benhamida, Yuniel Fernandez-Marrero, Borhane Annabi   +4 more
doaj   +1 more source

Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]

, 2020
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu, Chan, Geraldine, Jablons, David M, Kyoyama, Hiroyuki, Li, Hui, Liu, Luwei, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Wang, Yucheng, Xu, Zhidong, Yang, Yi-Lin, You, Liang   +12 more
core  

Brachytherapy Approach Using ¹⁷⁷Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

Pharmaceutics, 2021
Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β−-emitter 177Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (177Lu-
Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, Yi-Jang Lee, Chun-Yi Wu   +9 more
doaj   +1 more source

Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems [PDF]

, 2014
HIF (hypoxia inducible factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information, and thus cell fate may ...
Bagnall, James, Bearon, Rachel, Fercher, Andreas, Herrmann, Anne, Leedale, Joe, Papkovsky, Dmitri, See, Violaine   +6 more
core   +1 more source

Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling [PDF]

, 2018
Mitochondria are dynamic organelles frequently undergoing fission and fusion events to maintain their integrity, bioenergetics and spatial distribution, which is fundamental to the processes of cell survival.
Bonuccelli, G, Lisanti, MP, Peiris-Pagès, M, Sotgia, F   +3 more
core   +1 more source

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy [PDF]

, 2017
Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis.
A C Belkina, B E Pearson, M Lavaei, N Rahimi, N Woolf, P A Bondzie, R D Meyer, V Chitalia   +7 more
core   +1 more source

Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway

Ecotoxicology and Environmental Safety, 2023
Background: The omnipresence of human phthalate (PAE) exposure is linked to various adverse health issues, including breast cancer. However, the effects of low-dose PAE exposure on breast cancer stem cells (BCSCs) and the underlying mechanism remain ...
Wan-shuang Cao, Meng-jiu Zhao, Yue Chen, Jian-yun Zhu, Chun-feng Xie, Xiao-ting Li, Shan-shan Geng, Cai-yun Zhong, Jin-yan Fu, Jie-shu Wu   +9 more
doaj   +1 more source

Canine Mammary Cancer Stem Cells are Radio- and Chemo- Resistant and Exhibit an Epithelial-Mesenchymal Transition Phenotype [PDF]

, 2011
Canine mammary carcinoma is the most common cancer among female dogs and is often fatal due to the development of distant metastases. In humans, solid tumors are made up of heterogeneous cell populations, which perform different roles in the tumor ...
Al-Hajj, Alejandro Cervantes-Arias, Argyle, Bankfalvi, Bao, Bapat, Benjamin, Bolos, Bonnet, Campeau, Chambers, Christiansen, Clarke, Cohen, Collins, Dalerba, David J. Argyle, Dean, Diehn, Diehn, Else, Eramo, Fang, Fidler, Francipane, Galli, Gidekel, Gupta, Khanna, Klopfleisch, Kudo-Saito, Lee, Lindblad-Toh, Lisa Y. Pang, Lo, Locke, Lombaerts, Ma, Mani, Morel, Moulton, Pan, Pang, Pang, Park, Penzo, Porrello, Priester, Reya, Ricci-Vitiani, Rivera, Rod W. Else, Schatton, Schneider, Sharma, Singh, Singh, Tang, Thiery, Thiery, Thomas, Todaro, Villa, Wellner, Wilson, Winquist, Withrow, Witta, Woodward, Wu, Yang, Yang, Zhou   +72 more
core   +2 more sources

Modeling tumorspheres reveals cancer stem cell niche building and plasticity [PDF]

Physica A: Statistical Mechanics and its Applications, 2019
Cancer stem cells have been shown to be critical to the development of a variety of solid cancers. The precise interplay mechanisms between cancer stem cells and the rest of a tissue are still not elucidated. To shed light on the interactions between stem and non-stem cancer cell populations we develop a two-population mathematical model, which is ...
Benitez, Lucia, Barberis, Lucas Miguel, Condat, Carlos   +2 more
openaire   +3 more sources

Acorus gramineus extract decreases cancer stem cell properties and stimulates ROS signaling pathway in HepG2 hepatocellular carcinoma cells

Pharmacological Research - Modern Chinese Medicine
ABTRACT: Background: Acorus gramineus is called “Shi Chang Pu'” in Chinese and has been used in traditional Chinese medicine (TCM) for over 2,000 years.
Van Hung Hoang, Thi Thanh Huong Le, Phu Hung Nguyen, Viet Hoang, Van Khang Pham, Thi Kieu Oanh Nguyen, Dinh Quang Hung Can   +6 more
doaj   +1 more source