Results 41 to 50 of about 5,827 (204)
Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy
Journal of Structural Biology, 2023 The advent of volume electron microscopy (vEM) has provided unprecedented insights into cellular and subcellular organization, revolutionizing our understanding of cancer biology. This study presents a previously unexplored comparative analysis of the ultrastructural disparities between cancer cells cultured as monolayers and tumorspheres.
Nickhil Jadav +7 more
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Cancer Medicine, 2018 The majority of ovarian cancer patients are diagnosed in late stages of the disease, in which the tumor cells have leaked into the peritoneum and are present as tumorspheres.
Siddik Sarkar +4 more
doaj +1 more source
PLoS ONE, 2017 Cancer stem cell survival is the leading factor for tumor recurrence after tumor-suppressive treatments. Therefore, specific and efficient inhibitors of cancer stemness must be discovered for reducing tumor recurrence.
Chun-Chia Cheng +10 more
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Immunobiology of solid cancers: cellular and molecular pathways as potential diagnostic and therapeutic targets [PDF]
, 2018 In the last four decades, tumor immunology has shed light on identity and functions of cells and molecules involved in tumor rejection through the involvement of the immune system [1].
Braicu, E. I. +3 more
core +3 more sources
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools [PDF]
, 2019 BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines of ...
Carnero Moya, Amancio +10 more
core +1 more source
Molecules, 2014 Cancer stem cells are a subset of cancer cells that initiate the growth of tumors. Low levels of cancer stem cells also exist in established cancer cell lines, and can be enriched in serum-free tumorsphere cultures.
Hsueh-Wei Chang +7 more
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Cancer Cell International, 2022 Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma (GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, which involve interrupting the ...
Jin-Kyoung Shim +15 more
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Aldh1 Expression and Activity Increase during Tumor Evolution in Sarcoma Cancer Stem Cell Populations [PDF]
, 2016 Tumors evolve from initial tumorigenic events into increasingly aggressive behaviors in a process usually driven by subpopulations of cancer stem cells (CSCs).
García Castro, Javier +6 more
core +3 more sources
Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres [PDF]
Journal of Translational Medicine, 2020 Abstract Background Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells.
Seon-Jin Yoon +10 more
openaire +4 more sources
Cellular & Molecular Biology Letters, 2019 Background Breast tumor growth and recurrence are driven by an infrequent population of breast tumor-initiating cells (BTIC). We and others have reported that the frequency of BTIC is orders of magnitude higher when breast tumor cells are propagated in ...
William D. Gwynne +6 more
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