PRMT5 Methylates and Stabilizes EphA2 via Inhibiting Its Ubiquitination and Degradation to Promote Nasopharyngeal Carcinoma Stem Cell Properties. [PDF]
MedComm (2020)PRMT5 binds and methylates EphA2, which stabilizes EphA2 via inhibiting Cbl‐mediated EphA2 ubiquitination degradation to promote NPC stemness. PRMT5‐derived peptide P20 disrupts PRMT5–EphA2 interaction, which degrades EphA2 via enhancing Cbl‐mediated EphA2 ubiquitination degradation to suppress NPC stemness.
Yu ZZ +16 more
europepmc +2 more sources
Profiling Anti-Apoptotic BCL-xL Protein Expression in Glioblastoma Tumorspheres [PDF]
Cancers, 2020 Glioblastoma (GBM) is one of the cancers with the worst prognosis, despite huge efforts to understand its unusual heterogeneity and aggressiveness. This is mainly due to glioblastoma stem cells (GSCs), which are also responsible for the frequent tumor recurrence following surgery, chemotherapy or radiotherapy.
Fanfone, Deborah +4 more
openaire +3 more sources
Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. [PDF]
PLoS ONE, 2011 Abnormal activation of the Sonic hedgehog (SHH) pathway has been described in a wide variety of human cancers and in cancer stem cells (CSCs), however, the role of SHH pathway in gastric CSCs has not been reported.
Zhou Song +9 more
doaj +1 more source
Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells [PDF]
, 2017 Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
et al,, Si, Sheng
core +6 more sources
Effect of CD44 binding peptide conjugated to an engineered inert matrix on maintenance of breast cancer stem cells and tumorsphere formation. [PDF]
PLoS ONE, 2013 As cancer cells are affected by many factors in their microenvironment, a major challenge is to isolate the effect of a specific factor on cancer stem cells (CSCs) while keeping other factors unchanged. We have developed a synthetic inert 3D polyethylene
Xiaoming Yang +4 more
doaj +1 more source
Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells. [PDF]
PLoS ONE, 2015 The growth and expression of cancer stem cells (CSCs) depend on many factors in the tumor microenvironment. The objective of this work was to investigate the effect of cancer cells' tissue origin on the optimum matrix stiffness for CSC growth and marker ...
Esmaiel Jabbari +3 more
doaj +1 more source
Translational Oncology, 2022 Background: Radiotherapy resistance is one of the major causes of rectal cancer treatment failure. LncRNA DLGAP1-AS2 participates in the progression of several cancers.
Sheng-Ying Xiao +5 more
doaj +1 more source
SOX2OT lncRNA Inhibition Suppresses the Stemness Characteristics of Esophageal Tumorspheres
Non-Coding RNA, 2022 Background: SOX2OT is a novel cancer associated long non-coding RNA (LncRNA) with higher expression in variable tumor tissues, including esophageal squamous cell carcinoma (ESCC). It also plays an important function in embryonic neuronal development.
Boshra Haghi +4 more
openaire +3 more sources
Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres [PDF]
Journal of Cancer Research and Clinical Oncology, 2020 Abstract Purpose Glioblastoma (GBM) is the most aggressive type of brain tumor and has poor survival outcomes, even after a combination of surgery, radiotherapy, and chemotherapy. Temozolomide is the only agent that has been shown to be effective against GBM, suggesting that combination of temozolomide with other agents may be more effective ...
Hyeong-Cheol Oh +11 more
openaire +3 more sources
Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a
Cell Death and Disease, 2022 Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis ...
Jan Clusmann +9 more
doaj +1 more source