Results 1 to 10 of about 5,827 (204)

In vitro Tumorsphere Formation Assays [PDF]

Bio-protocol, 2013
A tumorsphere is a solid, spherical formation developed from the proliferation of one cancer stem/progenitor cell. These tumorspheres (Figure 1a) are easily distinguishable from single or aggregated cells (Figure 1b) as the cells appear to become fused ...
Sara Johnson, Hexin Chen, Pang-Kuo Lo
exaly   +5 more sources

Critical Role of Three-Dimensional Tumorsphere Size on Experimental Outcome [PDF]

BioTechniques, 2020
Three-dimensional in vitro spheroids are a reliable model to study tumor biology and drug toxicity. However, inconsistencies exist in terms of seeding cell density that governs spheroid size and shape, influencing the experimental outcome.
Swasti Tiwari, Meenakshi Tiwari
exaly   +5 more sources

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres [PDF]

BMC Cancer, 2008
Background MicroRNAs (miRNAs), some of which function as oncogenes or tumor suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell death. MicroRNA miR-34 was recently found to be a direct target of p53, functioning
DeSano Jeffrey, Zhang Min, Meng Yang, Hao Xinbao, Ji Qing, Fan Daiming, Xu Liang   +6 more
doaj   +10 more sources

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy [PDF]

eLife, 2019
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence.
Carlos J Diaz Osterman, Duygu Ozmadenci, Elizabeth G Kleinschmidt, Kristin N Taylor, Allison M Barrie, Shulin Jiang, Lisa M Bean, Florian J Sulzmaier, Christine Jean, Isabelle Tancioni, Kristen Anderson, Sean Uryu, Edward A Cordasco, Jian Li, Xiao Lei Chen, Guo Fu, Marjaana Ojalill, Pekka Rappu, Jyrki Heino, Adam M Mark, Guorong Xu, Kathleen M Fisch, Vihren N Kolev, David T Weaver, Jonathan A Pachter, Balázs Győrffy, Michael T McHale, Denise C Connolly, Alfredo Molinolo, Dwayne G Stupack, David D Schlaepfer   +30 more
doaj   +4 more sources

PLA2 driven lipid signaling drives ARMS tumorigenic cell properties [PDF]

Cell Communication and Signaling
Background Advancements in chemotherapy have improved outcomes for rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children. However, relapse-free survival rates remain below 20% in metastatic alveolar rhabdomyosarcoma (ARMS).
Amogh Gupta, Bharathi Ramanathan, Dipanwita Das, Aiswariya Vadivellu, Amos Hong Pheng Loh, Reshma Taneja   +5 more
doaj   +2 more sources

Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells

Cells, 2021
Recently, natural compounds have been used globally for cancer treatment studies. Silibinin is a natural compound extracted from Silybum marianum (milk thistle), which has been suggested as an anticancer drug through various studies.
Dong Young Kang, Nipin Sp, Jin-Moo Lee
exaly   +3 more sources

Metformin enhances alpelisib sensitivity in HER2+ breast cancer by suppressing cancer stemness and oncogenic signaling [PDF]

Frontiers in Oncology
IntroductionAlpelisib, a selective PI3Kα inhibitor that targets PIK3CA mutations, is approved for hormone receptor–positive, HER2-negative breast cancer. However, its therapeutic potential in HER2-positive disease remains underexplored.
Yujie Shi, Yujie Shi, Peijia Niu, Qiong Cheng, Lexia Chen, Yahan Weng, Xiaohe Yang   +6 more
doaj   +2 more sources

Combined treatment using bismuth sulfide nanoparticles loaded with NANOG decoy oligodeoxynucleotides under X-ray radiation for breast cancer cells [PDF]

Scientific Reports
Our goal in this study was to develop bismuth sulfide nanoparticles (NPs) that were functionalized with chitosan and incorporated with decoy oligodeoxynucleotides (ODNs) specifically targeting the NANOG transcription factor (designated as Bi@Chi-DEC NPs)
Sara Heidari, Mahmoud Gharbavi, Roghayeh Ghorbani, Hamed Rezaeejam, Behrooz Johari   +4 more
doaj   +2 more sources

Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells

Biomedicines, 2021
Targeted therapy based on natural compounds is one of the best approaches against non-small cell lung cancer. Ursolic acid (UA), a pentacyclic triterpenoid derived from medicinal herbs, has anticancer activity.
Dong Young Kang, Nipin Sp, Jin-Moo Lee, Kyoung-Jin Jang   +3 more
doaj   +1 more source

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres

Molecules, 2021
Resident cancer cells with stem cell-like features induce drug tolerance, facilitating survival of glioblastoma (GBM). We previously showed that strategies targeting tumor bioenergetics present a novel emerging avenue for treatment of GBM.
Hun Ho Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Soo Youl Kim, Seok-Gu Kang   +8 more
doaj   +1 more source