Results 31 to 40 of about 5,827 (204)
Frontiers in Oncology, 2017 Therapy resistance and tumor recurrence are often linked to a small refractory and highly tumorigenic subpopulation of neoplastic cells, known as cancer stem cells (CSCs). A putative marker of CSCs is CD133 (prominin-1).
Dina Kleinlützum +12 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2020 Background Exosomal microRNAs (miRNAs or miRs) from bone marrow-derived mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic strategies for cancer treatment.
Zhanfeng He +4 more
doaj +1 more source
A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model. [PDF]
PLoS ONE, 2014 Tumorsphere culture enriches and expands tumor cells, thus providing important resources for cancer studies. However, as compared with metastatic tissues, primary tumors in the nervous system rarely give rise to long-surviving tumorspheres, thereby ...
Dongliang Cao +6 more
doaj +1 more source
Lung tumorspheres as a drug screening platform against cancer stem cells [PDF]
Annals of Oncology, 2019 Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was to characterize lung CSCs and discover new therapeutic strategies.
Herreros Pomares, Alejandro +12 more
openaire +4 more sources
PLoS ONE, 2021 The cancer stem cell (CSC) concept proposes that cancer recurrence and metastasis are driven by CSCs. In this study, we investigated whether cells from colon adenocarcinoma (CA) with a CSC-like phenotype express renin-angiotensin system (RAS) components,
Matthew J Munro +3 more
doaj +1 more source
Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
Translational Oncology, 2022 The resistance of highly aggressive glioblastoma multiforme (GBM) to chemotherapy is a major clinical problem resulting in a poor prognosis. GBM contains a rare population of self-renewing cancer stem cells (CSCs) that proliferate, spurring the growth of
Kum Hee Noh +10 more
doaj +1 more source
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]
, 2017 Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao +18 more
core +1 more source
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]
, 2017 Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio +4 more
core +1 more source
The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis [PDF]
, 2016 Background The tumor microenvironment has complex effects in cancer pathophysiology that are not fully understood. Most cancer therapies are directed against malignant cells specifically, leaving pro-malignant signals from the microenvironment ...
Buchsbaum, Rachel J. +6 more
core +5 more sources
FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]
, 2017 Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria +3 more
core +2 more sources