Results 11 to 20 of about 5,827 (204)

Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments. [PDF]

PLoS ONE, 2011
Estrogen signaling plays a critical role in the pathogenesis of breast cancer. Because the majority of breast carcinomas express the estrogen receptor ERα, endocrine therapy that impedes estrogen-ER signaling reduces breast cancer mortality and has ...
Ada Ao, Brian J Morrison, Heiman Wang, J Alejandro López, Brent A Reynolds, Jianrong Lu   +5 more
doaj   +4 more sources

Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation [PDF]

Cancer Cell International, 2016
Background: A trend of stage-by-stage increase in tumorsphere (TS) formation from glioma samples has been reported. Despite this trend, not all surgical specimens give rise to TSs, even World Health Organization (WHO) grade IV gliomas.
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core   +6 more sources

Assessing the distribution of cancer stem cells in tumorspheres

Scientific Reports
Cancer Stem Cells presumably drive tumor growth and resistance to conventional cancer treatments. From a previous computational model, we inferred that these cells are not uniformly distributed in the bulk of a tumorsphere.
Jerónimo Fotinós, María Paula Marks, Lucas Barberis, Luciano Vellón   +3 more
doaj   +5 more sources

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres [PDF]

Journal of Translational Medicine, 2015
BackgroundThe STAT3 transcription factor is a major intracellular signaling protein and is frequently dysregulated in the most common and lethal brain malignancy in adults, glioblastoma multiforme (GBM).
Fang Guo, Milan Makale, Natsuko Nomura, Pengfei Jiang, Rajesh Mukthavaram, Rohit Saklecha, Sandeep C Pingle, Santosh Kesari, Xiao Ouyang   +8 more
core   +6 more sources

NDUFS1-Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation. [PDF]

MedComm (2020)
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Fan XY, Li W, Shi Y, Xu BQ, Wang H, Tian RF, Duan ZC, Fan J, Liu JR, Sun XX, Wang B, Wang LJ, Wang K, Wang SJ, Yang XM, Cui HY, Chen ZN, Li L.   +17 more
europepmc   +2 more sources

Understanding the influence of substrate when growing tumorspheres [PDF]

BMC Cancer, 2020
Abstract Background Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell dynamics.
Lucía Benítez, Lucas Barberis, Luciano Vellón, Carlos Alberto Condat   +3 more
openaire   +4 more sources

Dual inhibition of CPT1A and G6PD suppresses glioblastoma tumorspheres

Journal of Neuro-Oncology, 2022
Limited treatment options are currently available for glioblastoma (GBM), an extremely lethal type of brain cancer. For a variety of tumor types, bioenergetic deprivation through inhibition of cancer-specific metabolic pathways has proven to be an effective therapeutic strategy.
Seo Jin, Kim, Soo Jeong, Park, Junseong, Park, Hye Joung, Cho, Jin-Kyoung, Shim, Jieun, Seon, Ran Joo, Choi, Seon-Jin, Yoon, Ju Hyung, Moon, Eui Hyun, Kim, Eui Kyo, Seo, Sun Ho, Kim, Hyun Sil, Kim, Wan-Yee, Teo, Jong Hee, Chang, Jong In, Yook, Seok-Gu, Kang   +16 more
openaire   +4 more sources

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17-Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC. [PDF]

Adv Sci (Weinh)
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Cui L, Si S, Ye M, Lin P, Zou M, Lin Y, Chen X, Guo B, Sun W, Zhao X.   +9 more
europepmc   +2 more sources

A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres

Journal of Neuro-Oncology, 2021
Glioblastoma (GBM) is a rapidly growing tumor in the central nervous system with altered metabolism. Depleting the bioenergetics of tumors with biguanides have been suggested as an effective therapeutic approach for treating GBMs. The purpose of this study was to determine the effects of IM1761065, a novel biguanide with improved pharmacokinetics, on ...
Tae Hoon Roh, Ji-Hyun Lee, Seo Jin Kim, Jin-Kyoung Shim, Junseong Park, Seon-Jin Yoon, Wan-Yee Teo, Se Hoon Kim, Jong Hee Chang, Seok-Gu Kang   +9 more
openaire   +3 more sources

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]

, 2016
Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta, Carradori, Simone, DE LUCA, Teresa, De Maria, Ruggero, Del Bufalo, Donatella, Desideri, Marianna, DI MARTILE, Marta, Eramo, Adriana, Gabellini, Chiara, Mai, Antonello, Milella, MICHELE STANISLAW, Rotili, Dante, Secci, Daniela, Sette, Giovanni, Trisciuoglio, Daniela   +14 more
core   +9 more sources