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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Journal of Visualized Experiments, 2019 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Although significant efforts have enabled the identification of common mutations associated with RMS and allowed discrimination of different RMS subtypes, major challenges still exist for the development of novel treatments to further improve prognosis.
Francesca Boscolo Sesillo +1 more
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Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells
Chemico-Biological Interactions, 2018Therapy by targeting cancer stem cells (CSCs) is an eligible method to eradicate malignant human tumors. A synthetic triepoxide derivative, teroxirone, was reported effective against the growth of human lung cancer cells by injuring cellular mitochondria functions.
Yu-Ling, Ni +3 more
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Tumorsphere assay provides more accurate prediction of in vivo responses to chemotherapeutics [PDF]
Biotechnology Letters, 2013 Although the sphere culture system has been widely used in stem cell biology, its application for drug screening is limited due to lack of standardized, rapid analytical tools. To optimize sphere cultures for in vitro screening of drugs, we evaluated the properties of primary tumor cells growing as tumorspheres and compared their chemosensitivity to ...
Soyoung, Kim, Caroline M, Alexander
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A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres
Apoptosis, 2017To fight cancer at its roots by targeting cancer stem cells is a promising approach for therapy. Previously, an indolylquinoline derivative, 3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline (EMMQ), was reported effectively inhibiting the growth of lung cancer cells through impairment of cellular mitochondria functions.
Yu-Ling, Ni +6 more
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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Journal of Visualized Experiments, 2020Cancer stem cells play a vital role against clinical therapies, contributing to tumor relapse. There are many oncogenes involved in tumorigenesis and the initiation of cancer stemness properties. Since gene expression in the formation of colorectal cancer-derived tumorspheres is unclear, it takes time to discover the mechanisms working on one gene at a
Chun-Chia, Cheng +3 more
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Hexagonally packed microwell plates for hypoxic microenvironment induction in tumorspheres
Journal of Industrial and Engineering Chemistry, 2019Abstract The growth of a solid tumor in a confined microenvironment leads to increased compression, hypoxic/nutrition gradient within the tumor. However, Tumorspheres (TSs) cultured in free of spatial confinement do not exhibit physiological compressive stress.
Dongbin Won +3 more
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Abstract 1553: S1PR1 directs tumorsphere proliferation in ovarian cancer
Cancer ResearchAbstract Despite the clinical efforts to improve detection and treatment of high-grade serous ovarian cancer (HGSOC), half of diagnosed women will die every year because of this disease. Notably, nearly all of them present with ascites at diagnosis, which is directly associated with poor prognosis.
Núria Gendrau-Sanclemente +12 more
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Circadian properties of cancer stem cells in glioma cell cultures and tumorspheres
Cancer Letters, 2014Increased cancer risk is linked to disruption of circadian rhythms. Cancer stem cells (CSCs) are a known cause of cancer aggressiveness, but their circadian properties have not been described. We discovered circadian rhythms in gene expression within C6 glioma tumorspheres enriched in CSCs and found that the circadian clock is particularly robust in ...
Vishal Premdev, Sharma +2 more
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Abstract B67: Cytotoxic effect of isothiouronium salt MF08 in tumorsphere model
Clinical Cancer Research, 2018Abstract Skin cancer is the most common type of cancer in Brazil and accounts for 25% of all registered cases. Within this group, melanoma is considered the most severe and aggressive due to the possibility of metastasis. Melanoma is responsible for 79% of skin cancer deaths.
Marjorie G. P. Marin +6 more
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A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres
WFNOS 2022 Abstract Book, 2022Tae Hoon Roh +2 more
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