Results 71 to 80 of about 291,257 (303)

Turbulence attenuation by large neutrally buoyant particles [PDF]

, 2015
Turbulence modulation by inertial-range-size, neutrally-buoyant particles is investigated experimentally in a von K\'arm\'an flow. Increasing the particle volume fraction $\Phi_\mathrm{v}$, maintaining constant impellers Reynolds number attenuates the ...
E. Bodenschatz, E.-W. Saw, Gatignol R., J. Bec, M. Cisse, M. Gibert   +5 more
core   +5 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Defective flow space limits the scaling up of turbulence bioreactors for platelet generation

Communications Engineering
To complement donor-dependent platelets supplies, we previously developed an ex vivo manufacturing system using induced pluripotent stem cell (iPSC)-derived expandable immortalized megakaryocyte progenitor cell lines (imMKCLs), and a turbulent flow ...
Haruki Okamoto, Kosuke Fujio, Sou Nakamura, Yasuo Harada, Hideki Hayashi, Natsumi Higashi, Atsushi Ninomiya, Ryota Tanaka, Naoshi Sugimoto, Naoya Takayama, Atsushi Kaneda, Akira Sawaguchi, Yoshikazu Kato, Koji Eto   +13 more
doaj   +1 more source

Numerical simulation of turbulent flow between shrouded contra-rotating disks

Advances in Mechanical Engineering, 2016
The turbulent flow between shrouded contra-rotating disks was numerically studied with a two-layer turbulence model and a modified Launder–Sharma low-Reynolds number k - ε model.
Shu-Xian Chen, Jing-Zhou Zhang, Xiao-Ming Tan, An-Qing Lai   +3 more
doaj   +1 more source

Asymptotic Multi-Layer Analysis of Wind Over Unsteady Monochromatic Surface Waves [PDF]

, 2013
Asymptotic multi-layer analyses and computation of solutions for turbulent flows over steady and unsteady monochromatic surface wave are reviewed, in the limits of low turbulent stresses and small wave amplitude.
Drullion, F., Hunt, J. C. R., Sajjadi, S. G.   +2 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Turbulent Heat Transfer over roughness: a comprehensive review of theories and turbulent flow structure

International Journal of Thermofluids
Turbulent heat transfer over rough surfaces is crucial in natural and industrial processes, yet it has received less attention than that of momentum transfer.
Mohammadreza Kadivar, Himani Garg
doaj   +1 more source

Generalized self-similar spectrum and the effect of large-scale in decaying homogeneous isotropic turbulence

New Journal of Physics, 2018
In statistically stationary conditions, the turbulent energy spectrum in a high Reynolds number flow exhibits a k ^−5/3 (Kolmogorov) regime, with a faster decay at larger, dissipative wavenumbers.
Ping-Fan Yang, Alain Pumir, Haitao Xu
doaj   +1 more source

Experimental measurements of unsteady turbulent boundary layers near separation [PDF]

Investigations conducted to document the behavior of turbulent boundary layers on flat surfaces that separate due to adverse pressure gradients are reported.
Simpson, R. L.
core   +1 more source