Results 51 to 60 of about 395,966 (258)

Optimizing novasomes: impact of oleic acid and co-surfactant ratio on posaconazole delivery: In vitro & Ex vivo pharmacokinetic study

Journal of Applied Pharmaceutical Research
Background: Posaconazole, currently available as a solid oral dosage form, possesses erratic pharmacokinetics that complicate dosing regimens and increase the risk of adverse effects and drug interactions. Hence, innovative strategies, especially topical
Tushar Rukari, Prashant L Pingale, Chandrashekhar D Upasani   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate

Molecules, 2016
As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge.
Malwina Lachowicz, Michał Kołodziejczyk, Marek Lukosek, Jacek Kosno, Paulina Olszewska, Paweł Szymański   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Chemical and Theoretical Studies for Corrosion Inhibition of Magnesium in Hydrochloric Acid by Tween 80 Surfactant

International Journal of Electrochemical Science, 2015
The aim of this paper is to study the corrosion inhibition of magnesium in hydrochloric acid by using tween 80 surfactant. The inhibition action of tween 80 was studied using hydrogen evolution and weight loss methods.
Salah Eid, Walid M.I. Hassan
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Stability studies of silymarin nanoemulsion containing Tween 80 as a surfactant

Journal of Pharmacy and Bioallied Sciences, 2015
Background: Silymarin, a flavonolignan from "milk thistle" (Silybum marianum) plant is used almost exclusively for hepatoprotection. Because of its low bioavailability, it was incorporated into a nanoemulsion formulation. The aim of the present study was
Rabea Parveen, Sanjula Baboota, Javed Ali, Alka Ahuja, Sayeed Ahmad   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Novel docetaxel-loaded nanoparticles based on PCL-Tween 80 copolymer for cancer treatment

International Journal of Nanomedicine, 2011
Yuandong Ma1,2*, Yi Zheng1,2*, Xiaowei Zeng1-3*, Liqin Jiang4, Hongbo Chen1,2, Ranyi Liu5, Laiqiang Huang1,2, Lin Mei1,21School of Life Sciences, Tsinghua University, Beijing, 2Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua ...
Mei L, Huang L, Liu R, Cheng H, Jiang L, Zeng X, Zheng Y, Ma Y   +7 more
doaj  

Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System

The Scientific World Journal, 2014
We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of
Aminu Umar Kura, Samer Hasan Hussein-Al-Ali, Mohd Zobir Hussein, Sharida Fakurazi   +3 more
doaj   +1 more source