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Scale-up in twin-screw wet granulation

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Mechanisms of twin screw melt granulation

Journal of Drug Delivery Science and Technology, 2021
Abstract Twin screw melt granulation is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. Twin screw melt granulation has been rapidly gaining interest over recent years in the pharmaceutical industry.
Tongzhou Liu, Nada Kittikunakorn, Yi Zhang, Feng Zhang   +3 more
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Twin screw granulation: Steps in granule growth

International Journal of Pharmaceutics, 2012
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied.
Ranjit M, Dhenge, James J, Cartwright, Michael J, Hounslow, Agba D, Salman   +3 more
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Twin screw wet granulation: Granule properties

Chemical Engineering Journal, 2010
Abstract Granulation is an important particle size enlargement process, used in many applications. Granulation has, for many years, been a batch process because of a greater knowledge base. However, the technique of using a twin screw granulator has been found to be very effective at granulating and is an attractive proposition for manufacturing ...
Ranjit M. Dhenge, Richard S. Fyles, James J. Cartwright, David G. Doughty, Michael J. Hounslow, Agba D. Salman   +5 more
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Twin screw wet granulation: Binder delivery

International Journal of Pharmaceutics, 2015
The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique.
Mohammed F, Saleh, Ranjit M, Dhenge, James J, Cartwright, Michael J, Hounslow, Agba D, Salman   +4 more
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Twin-screw melt granulation: Current progress and challenges

International Journal of Pharmaceutics, 2020
Twin-screw melt granulation (TSMG) is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. TSMG has rapidly gained interest over recent years in the pharmaceutical industry. Since it is an inherently continuous process with controlled temperature and shear history, TSMG produces products with ...
Nada Kittikunakorn, Tongzhou Liu, Feng Zhang   +2 more
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Granulation of increasingly hydrophobic formulations using a twin screw granulator

International Journal of Pharmaceutics, 2014
The application of twin screw granulation in the pharmaceutical industry has generated increasing interest due to its suitability for continuous processing. However, an understanding of the impact of formulation properties such as hydrophobicity on intermediate and finished product quality has not yet been established.
Shen, Yu, Gavin K, Reynolds, Zhenyu, Huang, Marcel, de Matas, Agba D, Salman   +4 more
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Heat assisted twin screw dry granulation

AIChE Journal, 2017
A new “assisted” dry granulation method has been devised for the twin‐screw granulator. The method may be beneficial to drug preparation as it limits heat exposure to only one barrel zone, much shorter than melt granulation. Its mechanism was investigated using four placebo formulations, each containing a polymer binder with a glass transition ...
Y. Liu, M. R. Thompson, K. P. O'Donnell, S. Ali   +3 more
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Twin screw wet granulation: The study of a continuous twin screw granulator using Positron Emission Particle Tracking (PEPT) technique

European Journal of Pharmaceutics and Biopharmaceutics, 2012
In this paper, Positron Emission Particle Tracking (PEPT) techniques are utilised to track the trajectory of single particles through the mixing and conveying zones of a Twin Screw Granulator (TSG). A TSG consisting of conveying zones and mixing zones is used in this study. The mixing zones are arranged with kneading discs at an angle of 30°, 60° or 90°
Kai T, Lee, Andy, Ingram, Neil A, Rowson
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Twin screw granulation – review of current progress

Drug Development and Industrial Pharmacy, 2014
Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but ...
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