Results 121 to 130 of about 583 (139)

Dissolution enhancement of carbamazepine using twin-screw melt granulation

European Journal of Pharmaceutics and Biopharmaceutics, 2020
The current study explored the twin-screw melt granulation (TSMG) as a potential technology for the water solubility enhancement of biopharmaceutical classification system (BCS) class II drugs. As a model drug, carbamazepine (CBZ) was formulated with three different polymers as melt granules produced in a co-rotating twin-screw granulator. Polyethylene
Kristina E, Steffens, Karl G, Wagner
openaire   +2 more sources

Twin screw wet granulation: Effects of properties of granulation liquid

Powder Technology, 2012
Abstract The effect of the properties of the granulation liquid, i.e. viscosity (amount of binder) and surface tension on residence time, torque and granule properties such as size, shape, structure, strength and flowability was studied in a co-rotating twin screw granulator.
Ranjit M. Dhenge, James J. Cartwright, Michael J. Hounslow, Agba D. Salman   +3 more
openaire   +1 more source

Comparison of two twin-screw extruders for continuous granulation

European Journal of Pharmaceutics and Biopharmaceutics, 2009
A comparison was made between two twin-screw extruders (APV Baker and Leistritz Micro) used for continuous wet granulation. Both extruders had similar screw configurations, based on the length-to-diameter ratio of the screws, existing out of a conveying zone of 20 D, i.e. 20 times the screw diameter and a granulation zone of 4D.
D, Djuric, B, Van Melkebeke, P, Kleinebudde, J P, Remon, C, Vervaet   +4 more
openaire   +2 more sources

Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

International Journal of Pharmaceutics, 2020
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG) (rotation speed of chopper/impeller and granulation time varied).
Kristina E, Steffens, Marvin B, Brenner, Michael U, Hartig, Marius, Monschke, Karl G, Wagner   +4 more
openaire   +2 more sources

Influence of filler selection on twin screw foam granulation

Drug Development and Industrial Pharmacy, 2013
The influence of filler selection in wet granulation was studied for the novel case where the binder is delivered as an unstable, semi-rigid aqueous foam to an extrusion process. The work primarily examined the impact of differing concentrations of microcrystalline cellulose (Avicel PH® 101) in a formulation with spray-dried α-lactose monohydrate ...
K E, Rocca, S, Weatherley, P J, Sheskey, M R, Thompson   +3 more
openaire   +2 more sources

Influence of granulation temperature on particle size distribution of granules in twin-screw granulation (TSG)

Pharmaceutical Development and Technology, 2019
This study investigated an influence of granulation temperature during twin-screw granulation (TSG) on particle size distributions (PSDs). The influence of the granulation temperature on granule size distributions varied, depending on the liquid to solid (L/S) ratio, the kind of binders, the method of binder addition, and the filler material.
Akihiko, Ito, Peter, Kleinebudde
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Regime map development for continuous twin screw granulation

Chemical Engineering Science, 2013
Abstract A promising method for continuous wet granulation is to pass powdered solids and binder through a twin-screw extruder, usually, as in this case, with co-rotating screws. In the current work, the relationship between operating conditions and product granule properties has been investigated using the same materials (microcrystalline cellulose ...
Wei-Da Tu, Andy Ingram, Jonathan Seville
openaire   +1 more source

Granule size distributions after twin-screw granulation – Do not forget the feeding systems

European Journal of Pharmaceutics and Biopharmaceutics, 2016
The aim of this study was to investigate the influence of qualitatively different powder feeder performances on resulting granule size distributions after twin-screw granulation of a highly drug loaded, hydrophobic mixture and a mannitol powder. It was shown that powder feeder related problems usually cannot be identified by trusting in the values ...
R, Meier, M, Thommes, N, Rasenack, K-P, Moll, M, Krumme, P, Kleinebudde   +5 more
openaire   +2 more sources

Unraveling local heat generation in twin-screw melt granulation

International Journal of Pharmaceutics
Granule growth in twin-screw melt granulation (TSMG) is driven by viscous and frictional heat dissipation at the kneading block. The formation of larger, stronger granules requires the screws to input more energy into processing the material, resulting in local heat generation (ΔTlocal), as indicated by difference between the peak granule temperature ...
Niyati Niranjan, Kodange, Adwait, Pradhan, Fengyuan, Yang, Kapish, Karan, Quyen, Schwing, Thomas, Durig, Feng, Zhang   +6 more
openaire   +2 more sources

Continuous Twin-Screw Granulation Processing

2022
Uttom Nandi, Tumpa Dey, Dennis Douroumis
openaire   +1 more source