Results 91 to 100 of about 376 (138)

Physicochemical changes and chemical degradation of gliclazide during twin-screw melt granulation

International Journal of Pharmaceutics, 2022
Using a miscible model formulation consisting of 80% gliclazide (GLZ) and 20% hydroxypropyl cellulose, we investigate how the twin-screw melt granulation process affects the chemical stability and process-induced physicochemical changes of the drug. No degradation was observed in the conveying section that leads to kneading element.
Tongzhou, Liu, Navpreet, Kaur, Beibei, Chen, Brian, Phillips, Shao-Yu, Chang, Fengyuan, Yang, Vivian, Bi, Thomas, Durig, Feng, Zhang   +8 more
openaire   +2 more sources

Elucidation of granulation mechanisms along the length of the barrel in continuous twin-screw melt granulation

International Journal of Pharmaceutics, 2023
In the pharmaceutical industry, innovative continuous manufacturing technologies such as twin-screw melt granulation (TSMG) are gaining more and more interest to process challenging formulations. To enable the implementation of TSMG, more elucidation of the process is required and this study provides a better understanding of the granule formation ...
S. Van de Steene, J. Van Renterghem, V. Vanhoorne, C. Vervaet, A. Kumar, T. De Beer   +5 more
openaire   +2 more sources

Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

International Journal of Pharmaceutics, 2020
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear granulator (HSG) (rotation speed of chopper/impeller and granulation time varied).
Kristina E, Steffens, Marvin B, Brenner, Michael U, Hartig, Marius, Monschke, Karl G, Wagner   +4 more
openaire   +2 more sources

Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen

AAPS PharmSciTech, 2020
This study investigated the effect of binder level on the physicochemical changes and tabletability of acetaminophen (APAP)-hydroxypropyl cellulose (HPC) granulated using twin-screw melt granulation. Even at 5% HPC level, the tablet tensile strength achieved up to 3.5 MPa. A minimum of 10% HPC was required for the process robustness.
Tongzhou, Liu, Shubhajit, Paul, Brian T, Beeson, Johnny, Alexander, Fengyuan, Yang, Vivian, Bi, Thomas, Durig, Changquan Calvin, Sun, Feng, Zhang   +8 more
openaire   +2 more sources

Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)

International Journal of Pharmaceutics, 2021
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was used to optimize the processing conditions using the % drug loading (X1) and screw speed (X2) as the independent ...
Hemanth K, Mamidi, Siddhant, Palekar, Pavan Kumar, Nukala, Saurabh M, Mishra, Manali, Patki, Yige, Fu, Piyush, Supner, Gautam, Chauhan, Ketan, Patel   +8 more
openaire   +2 more sources

Melt granulation using a twin-screw extruder: A case study

International Journal of Pharmaceutics, 2006
The purpose of this study was to use a twin-screw extruder for melt granulation. Polyethylene glycols (PEG 400 and 4000) were used as binders for the development of a drinking water formulation with immediate drug release. The effect of drug content, PEG 400/4000-ratio, surfactant (type and concentration) and granulation temperature on granule ...
Barbara, Van Melkebeke, Brenda, Vermeulen, Chris, Vervaet, Jean Paul, Remon   +3 more
openaire   +2 more sources

Binder-free twin-screw melt granulation: An effective approach to manufacture high-dose API formulations

International Journal of Pharmaceutics, 2021
This study investigates the use of twin-screw binder-free melt granulation (BFMG) in the development of high-dose solid dose formulations for low melting point thermally stable drugs. Both ibuprofen and guaifenesin are examined. By granulating pure API powder, it is shown that BFMG can successfully be used to produce granules that contain 100% API.
Cotabarren, Ivana María, Omar, Thamer A., Muzzio, Fernando Javier   +2 more
openaire   +3 more sources

Application of Twin-Screw Melt Granulation to Overcome the Poor Tabletability of a High Dose Drug

Pharmaceutical Research, 2022
Pharmaceutical tablet manufacturing has seen a paradigm shift toward continuous manufacturing and twin-screw granulation-based technologies have catalyzed this shift. Twin-screw granulator can simultaneously perform unit operations like mixing, granulation, and drying of the granules.
Samarth D, Thakore, Katangur Vishruth, Reddy, Ajay K, Dantuluri, Deepika, Patel, Akshant, Kumawat, Vaibhav, Sihorkar, Chinmay, Ghoroi, Arvind K, Bansal   +7 more
openaire   +2 more sources

Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution

International Journal of Pharmaceutics, 2019
In this study, the impact of binder distribution on the tabletability and compactibility of granules produced by twin-screw melt granulation was investigated. To this end, two grades of dicalcium phosphate anhydrous (fine and coarse) were used as model substances (filler) in combination with two grades of poloxamer (fine and coarse) as melt binder at ...
Kristina E, Steffens, Karl G, Wagner
openaire   +2 more sources

Visualization of the granule temperature using thermal imaging to improve understanding of the granulation mechanism in continuous twin-screw melt granulation

International Journal of Pharmaceutics, 2023
The aim of this study is to increase process understanding of the granulation mechanism in twin-screw melt granulation by evaluating the influence of different screw configurations on granule formation and granule temperature via thermal imaging. The study used a Design of Experiments (DoE) to process a miscible and immiscible formulation (85% API ...
S. Van de Steene, J. Van Renterghem, V. Vanhoorne, C. Vervaet, A. Kumar, T. De Beer   +5 more
openaire   +2 more sources