Results 101 to 110 of about 376 (138)
Some of the next articles are maybe not open access.
Powder Technology, 2020
Abstract This study focuses on the impact of initial particle size on the tabletability and the deformation behaviour (i.e. plasticity) of granules produced by twin-screw melt granulation (TSMG). As model substances, three different grades of anhydrous dicalcium phosphate (aDCP) were melt-granulated with polyethylene glycol 6000 (PEG) using a twin ...
Kristina E. Steffens, Karl G. Wagner
openaire +1 more source
Abstract This study focuses on the impact of initial particle size on the tabletability and the deformation behaviour (i.e. plasticity) of granules produced by twin-screw melt granulation (TSMG). As model substances, three different grades of anhydrous dicalcium phosphate (aDCP) were melt-granulated with polyethylene glycol 6000 (PEG) using a twin ...
Kristina E. Steffens, Karl G. Wagner
openaire +1 more source
Drug Development and Industrial Pharmacy, 2022
This work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and commercial transfer of high drug load (80.5% w/w) immediate release fevipiprant tablets.The unique and compelling learnings from this industry work are (1) insights into Novartis AG's commercial
Claudia Vicente Martin +8 more
openaire +2 more sources
This work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and commercial transfer of high drug load (80.5% w/w) immediate release fevipiprant tablets.The unique and compelling learnings from this industry work are (1) insights into Novartis AG's commercial
Claudia Vicente Martin +8 more
openaire +2 more sources
International Journal of Pharmaceutics, 2023
Twin-screw melt granulation (TSMG) is a promising continuous manufacturing technology for the processing of high drug load formulations and to formulate heat- and moisture-sensitive active pharmaceutical ingredients (APIs). This study evaluates the influence of process parameters for TSMG, mainly focusing on the effect of the screw configuration ...
S, Van de Steene +5 more
openaire +2 more sources
Twin-screw melt granulation (TSMG) is a promising continuous manufacturing technology for the processing of high drug load formulations and to formulate heat- and moisture-sensitive active pharmaceutical ingredients (APIs). This study evaluates the influence of process parameters for TSMG, mainly focusing on the effect of the screw configuration ...
S, Van de Steene +5 more
openaire +2 more sources
Continuous twin-screw melt granulation of poorly compressible and thermal labile drug
2020Continuous twin-screw melt granulation (TSMG) has been widely used for the last 50 years in various industrial processes. For pharmaceutical manufacturing, TSMG offers many advantages over continuous twin-screw wet granulation and roller compaction.
Kittikunakorn, Nada, 0000-0001-5442-6128
openaire +2 more sources
Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
International Journal of PharmaceuticsTwin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive research conducted on the impact of screw geometry in melt compounding, there is not enough literature for TSMG.
Adwait Pradhan +7 more
openaire +2 more sources
Unraveling local heat generation in twin-screw melt granulation
International Journal of PharmaceuticsGranule growth in twin-screw melt granulation (TSMG) is driven by viscous and frictional heat dissipation at the kneading block. The formation of larger, stronger granules requires the screws to input more energy into processing the material, resulting in local heat generation (ΔTlocal), as indicated by difference between the peak granule temperature ...
Niyati Niranjan, Kodange +6 more
openaire +2 more sources
International Journal of Pharmaceutics, 2019
The effect of thermal binders on the physicochemical properties of gabapentin, a thermally labile drug, in granules prepared using twin-screw melt granulation was investigated in this study. Hydroxypropyl cellulose (HPC), a thermoplastic high molecular-weight binder, was compared against conventional low molecular-weight semi-crystalline thermal ...
Nada Kittikunakorn +4 more
openaire +2 more sources
The effect of thermal binders on the physicochemical properties of gabapentin, a thermally labile drug, in granules prepared using twin-screw melt granulation was investigated in this study. Hydroxypropyl cellulose (HPC), a thermoplastic high molecular-weight binder, was compared against conventional low molecular-weight semi-crystalline thermal ...
Nada Kittikunakorn +4 more
openaire +2 more sources
Examining the mechanics of granulation with a hot melt binder in a twin-screw extruder
Chemical Engineering Science, 2012Abstract Hot melt granulation involves particle enlargement with a binder that is in its molten state during processing with accompanying solids. Fundamental studies of the technique have been presented for high shear mixers and fluidized bed systems in the literature but with the recent interest in twin screw extrusion machinery by the ...
B. Mu, M.R. Thompson
openaire +1 more source
Journal of Pharmaceutical Sciences, 2013
Hot-melt granulation (HMG) by twin screw extrusion is a novel technology for the continuous processing of pharmaceuticals but confidence must still be gained regarding whether the environment affects drug properties. In this preliminary study, granulation was studied for a model product containing lactose monohydrate and active ingredients of differing
Sharleen, Weatherley +4 more
openaire +2 more sources
Hot-melt granulation (HMG) by twin screw extrusion is a novel technology for the continuous processing of pharmaceuticals but confidence must still be gained regarding whether the environment affects drug properties. In this preliminary study, granulation was studied for a model product containing lactose monohydrate and active ingredients of differing
Sharleen, Weatherley +4 more
openaire +2 more sources
International Journal of Pharmaceutics, 2016
Twin-screw hot melt granulation (TS HMG) is a valuable, but still unexplored alternative to granulate temperature and moisture sensitive drugs in a continuous way. Recently, the material behavior of an immiscible drug-binder blend during TS HMG was unraveled by using a rheometer and differential scanning calorimetry (DSC).
Tinne, Monteyne +7 more
openaire +2 more sources
Twin-screw hot melt granulation (TS HMG) is a valuable, but still unexplored alternative to granulate temperature and moisture sensitive drugs in a continuous way. Recently, the material behavior of an immiscible drug-binder blend during TS HMG was unraveled by using a rheometer and differential scanning calorimetry (DSC).
Tinne, Monteyne +7 more
openaire +2 more sources